Richard A. Flavell

TL;DR: It is demonstrated here that T-cell–specific blockade of TGF-β signaling allows the generation of an immune response capable of eradicating tumors in mice challenged with live tumor cells.

TL;DR: An example of eukaryotic genes located on separate chromosomes associating physically in the nucleus via interactions that may have a function in coordinating gene expression is provided and there seems to be a cell-type-specific dynamic interaction between interacting chromatin partners whereby interchromosomal interactions are apparently lost in favour of intrachromosomal ones upon gene activation.

TL;DR: Monitoring the homing, expansion, and effector function of both subsets in draining and nondraining lymph nodes shows that CD8 cells expand to the same extent and produce similar levels of IFN-γ in the presence or absence of Ag-specific Treg, which abrogate CD8 T cell-mediated tumor rejection by specifically suppressing the cytotoxicity of expandedCD8 cells.

TL;DR: In this paper, the role of transforming growth factor-beta (TGF-beta) in inhibiting T cell functions has been studied with dominant negative TGF-β receptor transgenic models.

TL;DR: In this article, the nucleotide-binding domain and leucine-rich repeat containing (NLR) gene family was defined and standardized gene designations for all family members were provided.