R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5
TL;DR: Enhanced promyogenic MAPK activity preserved muscle stem cell function even in the absence of dystrophin and ultimately curtailed the pathogenesis associated with DMD, suggesting that MKP-5 may serve as a target to promote muscle stem Cell function in the treatment of degenerative skeletal muscle diseases.
Book ChapterDOI
The intestinal microbiota in chronic liver disease.
TL;DR: It is now evident that, during pathological processes associated with obesity, alcohol-intake, or autoimmunity, the interaction between these immune cell populations and the intestinal microbiota promotes chronic liver disease progression and therefore they represent a novel therapeutic target.
Journal ArticleDOI
Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.
Walter K. Mowel,Sam J. McCright,Jonathan J. Kotzin,Magalie A. Collet,Asli Uyar,Xin Chen,Alexandra DeLaney,Sean P. Spencer,Anthony Virtue,En Jun Yang,Alejandro V. Villarino,Makoto Kurachi,Margaret C. Dunagin,Gretchen Harms Pritchard,Judith Stein,Judith Stein,Cynthia Hughes,Cynthia Hughes,Diogo Fonseca-Pereira,Henrique Veiga-Fernandes,Arjun Raj,Taku Kambayashi,Igor E. Brodsky,John J. O'Shea,E. John Wherry,Loyal A. Goff,John L. Rinn,Adam Williams,Richard A. Flavell,Richard A. Flavell,Jorge Henao-Mejia,Jorge Henao-Mejia +31 more
TL;DR: A cis-regulatory element demarcated by a long non-coding RNA (lncRNA) that controls the function and lineage identity of group 1 ILCs, while being dispensable for early ILC development and homeostasis of ILC2s and ILC3s is identified.
Journal ArticleDOI
Transforming Growth Factor-β Suppresses the Activation of CD8+ T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced : A Two-Faced Impact on Autoimmunity
Christophe M. Filippi,Amy E. Juedes,Janine Oldham,Ellie Ling,Lisa Togher,Yufeng Peng,Richard A. Flavell,Matthias von Herrath +7 more
TL;DR: When expressed selectively in the pancreas, TGF-β reduced apoptosis of differentiated autoreactive CD8+ T-cells, favoring their expansion and infiltration of the islets, highlighting a novel aspect of the pleiotropic nature of TGF, which has implications for the design of immune therapies involving this cytokine.
Journal ArticleDOI
Epigenetic and Transcriptional Programs Lead to Default IFN-γ Production by γδ T Cells
Liang Chen,Weifeng He,Sean T. Kim,Jian Tao,Yunfei Gao,Hongbo Chi,Andrew M. Intlekofer,Bohdan P. Harvey,Steven L. Reiner,Zhinan Yin,Richard A. Flavell,Joe Craft +11 more
TL;DR: It is shown that the kinetics of IFN-γ transcription is faster in γδ T cells compared with CD4+ and CD8+ T cells and that γ Δ T cells produce significantly greater amounts of IFn-γ in a proliferation-independent manner when compared with other T cell subsets.