R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor
Mohamed Bellahcene,Sebastien Jacquet,Xue B. Cao,Masaya Tanno,Robert S. Haworth,Joanne Layland,Alamgir Kabir,Matthias Gaestel,Roger J. Davis,Richard A. Flavell,Ajay M. Shah,Metin Avkiran,Michael S. Marber +12 more
TL;DR: Tumor necrosis factor activates p38-MAPK in the intact heart and in isolated cardiac myocytes through MKK3, and this activation likely contributes to the early cardiodepressant action of TNFalpha.
Journal ArticleDOI
Rapid induction of a novel costimulatory activity on B cells by CD40 ligand
Yan Wu,Jianchao Xu,Sanjay Shinde,Iqbal S. Grewal,Tanya Henderson,Richard A. Flavell,Yang Liu +6 more
TL;DR: It is shown that T cells from Cd40L-deficient mice induce a substantially reduced costimulatory activity on B cells compared to wild-type T cells, particularly at early time points.
Journal ArticleDOI
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.
Sandip Mukherjee,Ritesh Kumar,Elviche Tsakem Lenou,Venkatesha Basrur,Dimitris L. Kontoyiannis,Fotis Ioakeimidis,George Mosialos,Arianne L. Theiss,Richard A. Flavell,K. Venuprasad +9 more
TL;DR: It is demonstrated that the deubiquitinase Cyld prevents excessive interleukin 18 (IL-18) production in the colonic mucosa by deubiqueitinating NLRP6, and a novel regulatory mechanism is identified that inhibits theNLRP6– IL-18 pathway in intestinal inflammation.
are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
Dragana Jankovic,Marika C. Kullberg,Carl G. Feng,Romina S. Goldszmid,Carmen M. Collazo,Mark R. Wilson,Thomas A. Wynn,Masahito Kamanaka,Richard A. Flavell,Alan Sher +9 more
TL;DR: Findings indicate that IL-10 production by CD4+ T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens.
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Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
Xiao-Hong Chen,Bharvin K.R. Patel,Ling-Mei Wang,Mark Frankel,Nelson Ellmore,Richard A. Flavell,William J. LaRochelle,Jacalyn H. Pierce +7 more
TL;DR: Evidence is provided that Jak1 expression is required for mediating tyrosine phosphorylation and activation of crucial molecules involved in IL-4 signal transduction.