R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice.
Armen Khachatryan,Sylvie Guerder,F. Palluault,Gilbert Cote,Michele Solimena,Karine Valentijn,Isabelle Millet,Richard A. Flavell,Agnès Vignery +8 more
TL;DR: The production of CGRP by beta cells prevented insulin-dependent diabetes mellitus in male and reduced its incidence by 63% in female mice, suggesting that C GRP is a potential therapeutic molecule to prevent or treat diabetes and possibly other diseases and conditions in which immune cells are involved.
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Macrophage and T cell produced IL-10 promotes viral chronicity.
Kirsten Richter,Guillaume Perriard,Rayk Behrendt,Reto A. Schwendener,Veronika Sexl,Robert R. Dunn,Masahito Kamanaka,Richard A. Flavell,Axel Roers,Annette Oxenius +9 more
TL;DR: The data suggest that the decision whether LCMV infection becomes chronic or can be cleared critically depends on early CD4+ T cell and monocyte/macrophage produced IL-10.
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Nuclear Receptor CAR Represses TNFα-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B
TL;DR: The present finding that CAR can repress cell death via its interaction with GADD45B provides an insight for further investigations into the CAR-regulated molecular mechanism by which PB promotes development of HCC.
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Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells.
Wenting Huang,Kritika Kachapati,David H. Adams,Yuehong Wu,Patrick S.C. Leung,Guo-Xiang Yang,Weici Zhang,Aftab A. Ansari,Richard A. Flavell,M. Eric Gershwin,William M. Ridgway +10 more
TL;DR: In this article, the authors showed that co-transfer of B6 Tregs prevented dnTGFβRII CD8 T cell mediated cholangitis in mice.
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The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases.
William Damsky,Danielle Peterson,Julie Y. Ramseier,Badr Al-Bawardy,Hyung J. Chun,Deborah D. Proctor,Vibeke Strand,Richard A. Flavell,Brett A. King +8 more
TL;DR: The biology of the JAK-STAT pathway and the use of JAK inhibitors to treat autoimmunity across medical subspecialties are reviewed.