Richard A. Flavell

TL;DR: It is demonstrated that secreted AMCase feeds back in an autocrine and/or paracrine manner to protect pulmonary epithelial cells from growth factor withdrawal- and Fas ligand-induced apoptosis and that the cytoprotection is mediated via a PI3K/Akt-dependent and allosamidin-sensitive pathway that is independent of the chitinolytic activity of this chitinase.

TL;DR: C-Jun/JNK is activated following DNA damage and it is proposed that c-Jun is regulated by the JNK and CDK pathways and that both must be activated for efficient c- Jun activation to occur.

TL;DR: Recent findings on proteins that control the fate of TH0 differentiation, whether by promotion or inhibition, are reviewed, and the role of epigenesis in the differentiation process is discussed.

TL;DR: It is shown that FAT10 knockout prevents the development of age-associated obesity in mice while extending lifespan and vigor without the appearance of deleterious developmental effects, and suggest novel roles of FAT10 in immune metabolic regulation that impact aging and chronic disease.

TL;DR: The data suggest that TNFalpha may act in vivo to modulate a potentially damaging self-reactive T cell response by inducing tolerance to pancreatic antigens.