R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses.
Håkan Hall,Margareta Wilhelm,Samuel D. Saibil,Tak W. Mak,Richard A. Flavell,Pamela S. Ohashi +5 more
TL;DR: A critical role for RIP2 in Nod signaling is demonstrated, while T cell proliferation, T helper differentiation and TLR responses were unaffected by the absence of RIP2.
Journal ArticleDOI
IL-10–producing forkhead box protein 3–negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus
Federica Facciotti,Nicola Gagliani,Barbara Häringer,Johanna Sophie Alfen,A.E. Penatti,Stefano Maglie,Moira Paroni,Andrea Iseppon,Monica Moro,Maria Cristina Crosti,K Stölzel,Chiara Romagnani,Gabriella Moroni,Francesca Ingegnoli,Sara Torretta,Lorenzo Pignataro,Andrea Annoni,Fabio Russo,Massimiliano Pagani,Sergio Abrignani,Pier Luigi Meroni,Richard A. Flavell,Richard A. Flavell,Jens Geginat +23 more
Journal ArticleDOI
Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling
TL;DR: The endocytosis regulator dynamin 2 is required for the regulation of S1 PR1 internalization and continued S1PR1 signaling in low S1P environments.
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NF-kappa B binds within a region required for B-cell-specific expression of major histocompatibility complex class II gene E alpha d.
TL;DR: A region upstream of the murine major histocompatibility complex gene, E alpha d, has been shown previously to be required for B-cell expression and binding of the B- cell-specific factor, NF-kappa B, to a site within this region is indistinguishable from that observed with the kappa enhancer binding site.
Journal ArticleDOI
Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells.
Philippe Pierre,Idit Shachar,Idit Shachar,Didi Matza,Evelina Gatti,Richard A. Flavell,Ira Mellman +6 more
TL;DR: It is demonstrated here that H2-M, which is required for efficient class II antigenic peptide loading, is unexpectedly downregulated in splenocytes and mature dendritic cells from Ii−/− mice.