R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity.
Enping Hong,Ilana Usiskin,Cristina Bergamaschi,Douglas Hanlon,Richard L. Edelson,Sune Justesen,George N. Pavlakis,Richard A. Flavell,Tarek M. Fahmy +8 more
TL;DR: It is found that trans-presenting IL-15:IL-15Rα in a multivalent fashion on the surface of antigen-encapsulating nanoparticles enhanced the ability of nanoparticle-treated dendritic cells (DCs) to stimulate antigen-specific CD8+ T cell responses.
Journal Article
B7-1 expression by a non-antigen presenting cell-derived tumor.
TL;DR: It is found that a tumor cell line derived from one such tumor expresses the T-cell costimulatory molecule B7-1, the expression of which is normally restricted to antigen-presenting cells, and several immortalized cell lines, which are nontumorigenic and thus have suffered only early genetic events in the tumorigenesis process, express B7.
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Murine leukemia virus sequences are encoded in the murine major histocompatibility complex
Daniel Meruelo,Ruth Kornreich,Anthony Rossomando,Christine Pampeno,Andrew L. Mellor,Elisabeth H. Weiss,Richard A. Flavell,Angel Pellicer +7 more
TL;DR: The studies reported here localize murine leukemia viral sequences to the TL region of the major histocompatibility complex, H-2, and suggest that the viral sequences detected appear to be linked to or inserted amid class I genes.
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Innate immune recognition of flagellin limits systemic persistence of Brucella
Matthieu Terwagne,Jonathan Ferooz,Hortensia G. Rolán,Yao Hui Sun,Vidya L. Atluri,Mariana N. Xavier,Luigi Franchi,Gabriel Núñez,Thomas Legrand,Richard A. Flavell,Xavier De Bolle,Jean-Jacques Letesson,Renée M. Tsolis +12 more
TL;DR: The use of cells and mice genetically deficient for different components of inflammasomes suggested that FliC was a target of the cytosolic innate immune receptor NLRC4 in vivo but not in macrophages in vitro, therefore suggesting a new pathway of cytOSolic flagellin sensing.
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Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent.
TL;DR: This domain (comprising amino acids 197 to 241) does not share significant homology with other bacterial flagellins and therefore may be useful in serological testing for Lyme disease, and was bound by sera from patients with late-stage Lyme disease.