R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions
Jijun Cheng,Jijun Cheng,Christine Roden,Christine Roden,Wen Pan,Wen Pan,Shu Zhu,Anna Baccei,Anna Baccei,Xinghua Pan,Tingting Jiang,Yuval Kluger,Sherman M. Weissman,Shangqin Guo,Shangqin Guo,Richard A. Flavell,Ye Ding,Jun Lu +17 more
TL;DR: A Molecular Chipper technology for generating dense sgRNA libraries for genomic regions of interest, and a proof-of-principle screen that identifies novel cis-regulatory domains for miR-142 biogenesis are presented.
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The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease.
TL;DR: The cloning and expression of the hook gene, flgE, of B. burgdorferi was cloned into an Escherichia coli expression plasmid, pMX, to produce FlgE protein, and the antiserum was found to react with a 40-kDa peptide in the whole-cell lysates, confirming the expression ofThe periplasmic flagellum of Borrelia burgorferi.
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How to define biomarkers of human T cell aging and immunocompetence
TL;DR: How aging affects the number, phenotype, and function of human naive and memory T cells, and how to identify and validate potential biomarkers of T cell aging are focused on.
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IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans.
Jan Kempski,Anastasios D. Giannou,Kristoffer Riecken,Lilan Zhao,Lilan Zhao,Babett Steglich,Jöran Lücke,Laura Garcia-Perez,Karl-Frederick Karstens,Anna Wöstemeier,Mikolaj Nawrocki,Penelope Pelczar,Mario Witkowski,Sven Nilsson,Leonie Konczalla,Ahmad Mustafa Shiri,Joanna Kempska,Ramez Wahib,Leonie Brockmann,Philipp Huber,Ann-Christin Gnirck,Jan-Eric Turner,Dimitra E. Zazara,Petra C. Arck,Alexander Stein,Ronald Simon,Anne Daubmann,Jan Meiners,Daniel Perez,Till Strowig,Pandelakis A. Koni,Andrey Kruglov,Andrey Kruglov,Guido Sauter,Jakob R. Izbicki,Andreas H. Guse,Thomas Rösch,Ansgar W. Lohse,Richard A. Flavell,Nicola Gagliani,Samuel Huber +40 more
TL;DR: Levels of IL22BP were decreased in human colorectal tumors, compared with nontumor tissues, and correlated with levels of lymphotoxin, which regulates expression of IL 22BP in colon tumors in mice and cultured human dendritic cells.
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T-Cell Activation: Two for T
TL;DR: T-cell activation requires costimulation in addition to the antigen-specific signal, and distinct costimulatory molecules can specifically activate different types of T-cell response.