R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB
Hubert Hilbi,Jeremy E. Moss,David S. Hersh,Yajing Chen,Josette Arondel,Subhashis Banerjee,Richard A. Flavell,Junying Yuan,Philippe J. Sansonetti,Arturo Zychlinsky +9 more
TL;DR: Data indicate that Shigella-induced apoptosis is distinct from other forms of apoptosis and seems uniquely dependent on Casp-1.
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Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6 MODEL OF NF-κB- AND MAP KINASE-DEPENDENT INFLAMMATION IN ADVANCED ATHEROSCLEROSIS
Yankun Li,Robert F. Schwabe,Tracie DeVries-Seimon,Pin Mei Yao,Marie-Christine Gerbod-Giannone,Alan R. Tall,Roger J. Davis,Richard A. Flavell,David A. Brenner,Ira Tabas +9 more
TL;DR: A novel scenario in which cytokines are induced in macrophages by endogenous cellular events triggered by excess ER cholesterol rather than by exogenous immune cell mediators is suggested, which may help explain the relationship between FC accumulation and inflammation in vulnerable plaques.
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Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor
Jeffrey C. Rathmell,Sarah E. Townsend,Jiachao C Xu,Richard A. Flavell,Christopher C. Goodnow +4 more
TL;DR: The need for both Fas and CD40L to correctly regulate self-reactive B cell fate may explain the severe autoantibody disorders in Fas- orCD40L-deficient children.
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Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
Terrence Town,Yasmina Laouar,Yasmina Laouar,Christopher Pittenger,Takashi Mori,Christine A. Szekely,Christine A. Szekely,Jun Tan,Ronald S. Duman,Richard A. Flavell +9 more
TL;DR: Results suggest that blockade of TGF-β–Smad2/3 signaling in peripheral macrophages represents a new therapeutic target for Alzheimer's disease.
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Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells
TL;DR: A critical role for PSR in early stages of mammalian organogenesis is demonstrated and it is suggested that this receptor may be involved in respiratory distress syndromes and congenital brain malformations.