R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Koichi Kobayashi,Mathias Chamaillard,Yasunori Ogura,Octavian Henegariu,Naohiro Inohara,Gabriel Núñez,Richard A. Flavell +6 more
TL;DR: It is shown that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod1-deficient mice, providing a possible mechanism for Nod 2 mutations in CD.
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Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Cathy Tournier,Patricia M. Hess,Derek D. Yang,Jie Xu,Tod K. Turner,Anjaruwee S. Nimnual,Dafna Bar-Sagi,Stephen N. Jones,Richard A. Flavell,Roger J. Davis +9 more
TL;DR: It is shown here that JNK is required for UV-induced apoptosis in primary murine embryonic fibroblasts, and data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway.
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BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
Emily H. Cheng,Michael C. Wei,Solly Weiler,Richard A. Flavell,Tak W. Mak,Tullia Lindsten,Stanley J. Korsmeyer +6 more
TL;DR: In mammals, BH3 domain-only molecules activate multidomain proapoptotic members to trigger a mitochondrial pathway, which both releases cytochrome c to activate caspases and initiates caspase-independent mitochondrial dysfunction.
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NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Eran Elinav,Till Strowig,Andrew L. Kau,Jorge Henao-Mejia,Christoph A. Thaiss,Carmen J. Booth,David R. Peaper,John Bertin,Stephanie C. Eisenbarth,Jeffrey I. Gordon,Richard A. Flavell,Richard A. Flavell +11 more
TL;DR: It is shown that deficiency of NLRP6 in mouse colonic epithelial cells results in reduced IL-18 levels and altered fecal microbiota characterized by expanded representation of the bacterial phyla Bacteroidetes (Prevotellaceae) and TM7.
Journal ArticleDOI
Reduced Apoptosis and Cytochrome c-Mediated Caspase Activation in Mice Lacking Caspase 9
Keisuke Kuida,Tarik F. Haydar,Chia-Yi Kuan,Yong Gu,Choji Taya,Hajime Karasuyama,Michael S.-S. Su,Pasko Rakic,Richard A. Flavell +8 more
TL;DR: Results indicate that Casp9 is a critical upstream activator of the caspase cascade in vivo, as indicated by the absence of Casp3-like cleavage and the restoration of cytochrome c-mediated cleavage after addition of in vitro-translated Casp 9.