R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
Papers
More filters
Journal ArticleDOI
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium.
Xuchen Zhang,Peiying Shan,Madhu Sasidhar,Geoffrey L. Chupp,Richard A. Flavell,Augustine M.K. Choi,Patty J. Lee +6 more
TL;DR: The data suggest that hyperoxia generates reactive oxygen species (ROS), which mediates cell death of lung epithelium via ERK1/2 MAPK activation, and functions upstream of caspase activation in lung epithelial cells.
Journal ArticleDOI
Domain interactions of H–2 class I antigens alter cytotoxic T-cell recognition sites
TL;DR: The pattern of CTL and monoclonal antibody recognition obtained indicates three correlations between structure and function of class I antigens, which suggests that a CTL site may be formed by amino acids from both domains 1 and 2, or that the conformation of amino acids at a C TL sites may be altered by interactions between domains 1 or 2.
Journal ArticleDOI
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
Padmini S. Pillai,Ryan D. Molony,Kimberly Martinod,Huiping Dong,Iris K. Pang,Michal Caspi Tal,Angel G. Solis,Piotr Bielecki,Subhasis Mohanty,Mark Trentalange,Robert J. Homer,Richard A. Flavell,Denisa D. Wagner,Ruth R. Montgomery,Albert C. Shaw,Peter Staeheli,Akiko Iwasaki,Akiko Iwasaki +17 more
TL;DR: It is reported that influenza-infected human monocytes, a type of immune cell, exhibit reduced antiviral activity and vulnerability to IAV disease is a function of caspase-dependent pathology.
Journal ArticleDOI
Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary.
Tiina Matikainen,Gloria I. Perez,Timothy S. Zheng,Thomas R. Kluzak,Bo R. Rueda,Richard A. Flavell,Jonathan L. Tilly +6 more
TL;DR: It is determined that oocyte death initiated as a result of either developmental cues or pathological insults was unaffected by the absence of caspase-3, and that the enzyme is dispensable for germ cell apoptosis in the female.
Journal ArticleDOI
Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing
Terrence Town,Fengwei Bai,Tian Wang,Tian Wang,Amber T. Kaplan,Feng Qian,Ruth R. Montgomery,John F. Anderson,Richard A. Flavell,Erol Fikrig +9 more
TL;DR: Results demonstrate that TLR7 and IL-23-dependent WNV responses represent a vital host defense mechanism that operates by affecting immune cell homing to infected target cells.