R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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T-cells in alzheimer’s disease
TL;DR: The use of mouse models of AD is explored as a system within which to definitively test the possible contribution of T-cells to AD pathogenesis and the recent Aβ immunotherapy approach vis-à-vis the activated, autoaggressive T-cell infiltrates that contributed to aseptic meningoencephalitis in a small percentage of patients is discussed.
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Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure
Neil C. Henderson,Katharine J Pollock,John Frew,Alison C. MacKinnon,Richard A. Flavell,Roger J. Davis,Tariq Sethi,Kenneth J. Simpson +7 more
TL;DR: Data demonstrated a central role for JNK in the pathogenesis of paracetamol-induced liver failure, thereby identifying JNK as an important therapeutic target in the treatment of par acetamol hepatotoxicity.
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Microglia recognize double-stranded RNA via TLR3.
TL;DR: Results demonstrate that microglia recognize dsRNA through TLR3 and associated signaling molecules and suggest that these cells are key sensors of ds RNA-producing viruses that may invade the CNS.
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A novel MHC class II epitope expressed in thymic medulla but not cortex
Donal B. Murphy,Donal B. Murphy,David Lo,Satyajit Rath,Ralph L. Brinster,Richard A. Flavell,Alfred E. Slanetz,Charles A. Janeway +7 more
TL;DR: A novel MHC class II epitope is described which is found on cells in thymic medulla but not cortex and is compatible with the hypothesis that different ligands, rather than different affinity thresholds for the same ligand, are involved in positive and negative selection of the T-cell repertoire.
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Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice.
Erol Fikrig,Stephen W. Barthold,Nancy Marcantonio,K. Deponte,Fred S. Kantor,Richard A. Flavell +5 more
TL;DR: It is suggested that OspA and OspB, but not flagellin, play roles in protective immunity to spirochete infection.