Richard A. Flavell

TL;DR: In this Perspective, critical differences between IL-17 itself and TH17 cells are highlighted and the protective nature of IL- 17 and Th17 cells is discussed.

TL;DR: Progressive renal failure in oxalate nephropathy results primarily from NALP3-mediated inflammation, thereby excluding differences in intestinal oxalates handling to explain the observed phenotype.

TL;DR: Recent studies demonstrating the important roles of innate pathogen receptors, including Toll-like receptors, nucleotide oligomerization domain containing proteins, and inflammasomes in mediating the inflammatory response to metabolic stress in different tissues are summarized and the interaction of innate pattern recognition receptors, gut microbiota, and nutrients are highlighted.

TL;DR: It is demonstrated that the number of effector CD8(+) T cells is tightly controlled by multiple extrinsic signals throughout effector differentiation; this plasticity should be exploited during vaccine design and immunotherapy against tumors and autoimmune diseases.

TL;DR: In this article, the authors used human IL-3/GM-CSF knock-in mice to study the human myeloid cell reconstitution in the lung and showed that these mice supported the development of human alveolar macrophages that partially rescued the pulmonary alveoral proteinosis syndrome.