R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
In vivo properties of monocyte chemoattractant protein-1.
Long Gu,Barbara J. Rutledge,Joseph Fiorillo,Catherine A. Ernst,Iqbal S. Grewal,Richard A. Flavell,Ron Gladue,Barrett J. Rollins +7 more
TL;DR: Results indicate that M CP‐1 expression at low levels in an anatomically confined area results in monocyte infiltration, suggesting that when properly expressed, MCP‐1's in vitro properties are reproduced in vivo.
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Transforming Growth Factor–β Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17–Dependent Pathway
Anton Gisterå,Anna-Karin L. Robertson,Anna-Karin L. Robertson,John Andersson,Daniel F. J. Ketelhuth,Olga Ovchinnikova,Stefan K. Nilsson,Anna M. Lundberg,Ming O. Li,Richard A. Flavell,Göran K. Hansson +10 more
TL;DR: It is reported that transforming growth factor–β (TGF-β) promotes plaque stabilization through the effects of interleukin-17 (IL-17), and this data link IL-17A to induction of a stable plaque phenotype, could lead to new plaque-stabilizing therapies, and should prompt an evaluation of cardiovascular events in patients treated with IL- 17 receptor blockade.
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Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice
Nicole Stowell,Jonathan Seideman,Holly Raymond,Karen A Smalley,Roberta J. Lamb,Devon D. Egenolf,Peter J. Bugelski,Lynne Murray,Marsters Paul,Rachel A Bunting,Richard A. Flavell,Lena Alexopoulou,Lani San Mateo,Don E. Griswold,Robert T. Sarisky,M. Lamine Mbow,Anuk Das +16 more
TL;DR: It is demonstrated that TLR3 activation by poly(I:C) modulates the local inflammatory response in the lung and suggest a critical role of TLR 3 activation in driving lung function impairment.
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The inflammasome in pathogen recognition and inflammation
TL;DR: It is proposed that membrane disruption leads to activation of the inflammasome, and the role of these molecules in host defense against pathogens and in autoinflammatory disorders is reviewed.
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How are T(H)1 and T(H)2 effector cells made
TL;DR: In this paper, the lineage specific genes are modified with epigenetic modifications, which result in the emergence of regulatory elements, which control high level lineage restricted expression by both intrachromosomal and interchromosomal associations.