Richard A. Flavell

TL;DR: It is shown that mouse peritoneal macrophages, but not splenic dendritic cells, produced IL-33 upon stimulation with LPS, and caspase-1-deficient, caspasase-8-treated, and calpain inhibitor-treated macrophage production was found even in caspases, suggesting that casp enzyme-1-, caspasing-8, andCalpain-independent IL- 33 production by macrophaging and/or mast

TL;DR: The recent advances in m6A research are summarized and the functional relevance and importance of m 6A modification in in vitro cell lines, in physiological contexts, and in cancers are highlighted.

TL;DR: It is reported that human CSF-1 knockin mice show augmented frequencies and functions of human myeloid cells, and human monocytes/macrophages obtained from the humanized CSFs engineered to express human cytokines show augmented functional properties including migration, phagocytosis, activation and responses to LPS.

TL;DR: The current picture that emerges indicates that CD40-CD40L interactions mediate many cell-mediated immune responses and T-cell-mediated effector functions that are required for proper functioning of the host defense system.

TL;DR: The importance of CD40-CD40L interactions in generating virus-specific CD4 T cell responses and in resolving chronic viral infection is highlighted.