R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches.
Thomas W. Spahn,Adriano Fontana,Ana Maria Caetano Faria,Anthony J. Slavin,Hans-Pietro Eugster,Xingmin Zhang,Pandelakis A. Koni,Nancy H. Ruddle,Richard A. Flavell,Paul D. Rennert,Howard L. Weiner +10 more
TL;DR: The results demonstrate that PP are not an absolute requirement for the induction of either high‐ or low‐dose oral tolerance, although oral tolerance could not be induced in animals devoid of both PP and MLN.
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Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease.
TL;DR: This Review summarizes the current understanding of the biology of mesenchymal cells of the intestinal lamina propria focusing mainly on fibroblasts and myofibroblast and discusses major open questions and current challenges in this field.
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Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-β Sensitivity In Vitro and In Vivo
TL;DR: These studies are the first to document that the E3 ubiquitin ligase Cbl-b plays an integral role in T cell T GF-β signaling, and that its absence results in multifunctional TGF-β-related defects that have important disease-related implications.
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MDP‐induced interleukin‐1β processing requires Nod2 and CIAS1/NALP3
Qilin Pan,John C. Mathison,Colleen Fearns,Vladimir V. Kravchenko,Jean da Silva Correia,Hal M. Hoffman,Koichi Kobayashi,John Bertin,Ethan P. Grant,Anthony J. Coyle,Fayyaz S. Sutterwala,Yasunori Ogura,Richard A. Flavell,Richard J. Ulevitch +13 more
TL;DR: Using mice bearing selective gene deletions, in vitro and in vivo data are provided showing that MDP‐induced IL‐1β release requires Nod2 and CIAS1/NALP3 as well as receptor‐interacting protein‐2 (Rip2), apoptosis‐associated speck‐like protein containing a caspase activation and recruitment domain (ASC), and caspases‐1.
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The translation of non-canonical open reading frames controls mucosal immunity
Ruaidhri Jackson,Lina Kroehling,Alexandra Khitun,Will Bailis,Abigail Jarret,Autumn G. York,Omair Khan,J Richard Brewer,Mathias H. Skadow,Coco Duizer,Christian C. D. Harman,Lelina Chang,Piotr Bielecki,Angel G. Solis,Holly R. Steach,Sarah A. Slavoff,Richard A. Flavell,Richard A. Flavell +17 more
TL;DR: It is proposed that the misannotation of non-canonical ORF-containing genes as non-Coding RNAs may obscure the essential role of a multitude of previously undiscovered protein-coding genes in immunity and disease.