R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Molecular biology of the H-2 histocompatibility complex
Richard A. Flavell,Hamish Allen,Linda C. Burkly,David H. Sherman,Gerald L. Waneck,Georg Widera +5 more
TL;DR: The H-2 histocompatibility complex of the mouse is a multigene family whose structure and organization have been established by molecular cloning, and their regulation and function is being defined by expression of the cloned genes.
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IL-13Rα2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice
Mark S. Wilson,Eldad Elnekave,Margaret M. Mentink-Kane,Marcus G. Hodges,John T. Pesce,Thirumalai R. Ramalingam,Robert W. Thompson,Masahito Kamanaka,Richard A. Flavell,Andrea Keane-Myers,Allen W. Cheever,Thomas A. Wynn +11 more
TL;DR: It is demonstrated that increased IL-13 receptor alpha 2 (IL-13Ralpha2) expression is responsible for the reduced AHR, mucus production, and fibrosis in BALB/c IL-10(-/-) mice.
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Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections
Jae Hyang Lim,Brigid Stirling,Jonathan M.J. Derry,Tomoaki Koga,Hirofumi Jono,Chang Hoon Woo,Haodong Xu,Patricia A. Bourne,Unhwan Ha,Hajime Ishinaga,Haidong Xu,Ali Andalibi,Xin-Hua Feng,Hongguang Zhu,Yuxian Huang,Yuxian Huang,Wenhong Zhang,Xinhua Weng,Chen Yan,Zhinan Yin,David E. Briles,Roger J. Davis,Richard A. Flavell,Jian Dong Li +23 more
TL;DR: CYLD was highly induced by PLY, and it inhibited MKK3-p38 kinase-dependent expression of plasminogen activator inhibitor-1 (PAI-1) in lung, thereby potentiating ALI and mortality, indicating a mechanism underlying the high early mortality of pneumococcal pneumonia.
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CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.
Kirk P. Townsend,Terrence Town,Takashi Mori,Takashi Mori,Lih-Fen Lue,Doug Shytle,Paul R. Sanberg,David G. Morgan,Francisco Fernandez,Richard A. Flavell,Jun Tan +10 more
TL;DR: It is shown that ligation of CD40 by CD40L modulates Aβ‐induced innate immune responses in microglia, including decreasedmicroglia phagocytosis of exogenous Aβ1–42 and increased production of pro‐inflammatory cytokines.
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NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
Stephanie C. Eisenbarth,Adam Williams,Oscar R. Colegio,Hailong Meng,Till Strowig,Anthony Rongvaux,Jorge Henao-Mejia,Christoph A. Thaiss,Sophie Joly,David Gonzalez,Lan Xu,Lauren A. Zenewicz,Ann M. Haberman,Eran Elinav,Steven H. Kleinstein,Fayyaz S. Sutterwala,Fayyaz S. Sutterwala,Richard A. Flavell +17 more
TL;DR: Adaptive immunity was impaired in the absence of NLRP10 because of a dendritic cell (DC) intrinsic defect in emigration from inflamed tissues, whereas upregulation of DC costimulatory molecules and chemotaxis to CCR7-dependent and -independent ligands remained intact.