R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Kevin A. Roth,Chia-Yi Kuan,Tarik F. Haydar,Cleta D’Sa-Eipper,K. S. Shindler,Timothy S. Zheng,Keisuke Kuida,Richard A. Flavell,Pasko Rakic +8 more
TL;DR: A role of programmed cell death is established in regulating the size of progenitor population in the central nervous system, a function that is distinct from the classic role of cell death in matching postmitotic neuronal population with postsynaptic targets.
Journal ArticleDOI
Requirement for Invariant Chain in B Cell Maturation and Function
Idit Shachar,Richard A. Flavell +1 more
TL;DR: It is shown that Ii is required for B cell development and participates by an unknown mechanism in B cell maturation.
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Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity
Hui-Ming Chen,William van der Touw,Yuan Shuo Wang,Kyeongah Kang,Sunny Mai,Jilu Zhang,Dayanira Alsina-Beauchamp,James A. Duty,Sathish Kumar Mungamuri,Bin Zhang,Thomas M. Moran,Richard A. Flavell,Stuart A. Aaronson,Hong-Ming Hu,Hisashi Arase,Suresh Ramanathan,Raja M. Flores,Ping-Ying Pan,Shu Hsia Chen +18 more
TL;DR: In this paper, the leukocyte immunoglobulin-like receptor B (LILRB) family members are negative regulators of myeloid cell activation, and LILRB2 antagonism inhibited receptor-mediated activation of SHP1/2 and enhanced proinflammatory responses.
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Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Marina Cella,Ramya Gamini,Cristiane Sécca,Patrick L. Collins,Patrick L. Collins,Shanrong Zhao,Vincent Peng,Michelle L. Robinette,Michelle L. Robinette,Jorge Schettini,Konstantin Zaitsev,Konstantin Zaitsev,William Gordon,Jennifer K. Bando,Kentaro Yomogida,Victor S. Cortez,Victor S. Cortez,Catrina Fronick,Robert S. Fulton,Lih Ling Lin,Susan Gilfillan,Richard A. Flavell,Liang Shan,Maxim N. Artyomov,Michael R. Bowman,Eugene M. Oltz,Eugene M. Oltz,Scott A. Jelinsky,Marco Colonna +28 more
TL;DR: It is shown that human innate lymphoid cells undergo conversion from ILC3s into ILC1-like cells in tissues in vivo, and that tissue factors and Aiolos were required for this process.
Journal ArticleDOI
Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate la gene function
Georg Widera,Linda C. Burkly,Carl A. Pinkert,Erik C. Böttger,C. Cowing,Richard D. Palmiter,Ralph L. Brinster,Richard A. Flavell +7 more
TL;DR: The E alpha MHC class II gene was introduced into (H-2b X s)F2 mice, and the presence of pBR327 DNA linked to the -1.4 kb E alpha transgene suppresses expression in peripheral adherent cells, yielding mice expressing E alpha only in the thymus.