R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Unraveling the Genetics of Autoimmunity
TL;DR: New genomic technologies applied to classic genetic studies involving twins, early onset cases, and phenotypic extremes may provide key insights into developmental and gene-environment interactions in autoimmunity.
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CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8+ Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection
Persephone Borrow,David F. Tough,Danelle S. Eto,Antoinette Tishon,Iqbal S. Grewal,Jonathan Sprent,Richard A. Flavell,Michael B. A. Oldstone +7 more
TL;DR: A previously unappreciated role for CD40L in the generation of CD8+ memory CTLp is suggested, as a consequence of defects in the CD4+ T-cell response mounted by these animals.
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An antibiotic-responsive mouse model of fulminant ulcerative colitis.
Silvia S. Kang,Seth M. Bloom,Lyse A. Norian,Michael Geske,Richard A. Flavell,Thaddeus S. Stappenbeck,Paul M. Allen +6 more
TL;DR: This work develops to their knowledge the first mouse model of fulminant ulcerative colitis by combining multiple genetic hits in immune regulation and demonstrates that the resulting disease is sensitive to both anticytokine therapy and broad-spectrum antibiotics.
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Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes.
TL;DR: Comparing signaling characteristics of 9 single-chain receptors consisting of the H-2K(b) extracellular and transmembrane domains and various combinations of T cell signal transduction domains shows that it is possible to link TCR, coreceptor, and costimulatory activities in a single functional entity using modular domains.
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Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice
Rabia Ballica,Karine Valentijn,Armen Khachatryan,Sylvie Guerder,Shanta E. Kapadia,Caren M. Gundberg,James P. Gilligan,Richard A. Flavell,Agnès Vignery +8 more
TL;DR: Targeting CGRP to osteoblasts appears to favor the establishment of a higher trabecular bone mass in mice, which is associated with an increased bone formation rate.