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Author

Richard B. Brown

Other affiliations: University of Michigan, IBM
Bio: Richard B. Brown is an academic researcher from University of Utah. The author has contributed to research in topics: CMOS & Membrane. The author has an hindex of 35, co-authored 210 publications receiving 7684 citations. Previous affiliations of Richard B. Brown include University of Michigan & IBM.


Papers
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Proceedings ArticleDOI
02 Dec 2001
TL;DR: A new version of SimpleScalar that has been adapted to the ARM instruction set is used to characterize the performance of the benchmarks using configurations similar to current and next generation embedded processors.
Abstract: This paper examines a set of commercially representative embedded programs and compares them to an existing benchmark suite, SPEC2000. A new version of SimpleScalar that has been adapted to the ARM instruction set is used to characterize the performance of the benchmarks using configurations similar to current and next generation embedded processors. Several characteristics distinguish the representative embedded programs from the existing SPEC benchmarks including instruction distribution, memory behavior, and available parallelism. The embedded benchmarks, called MiBench, are freely available to all researchers.

3,548 citations

Journal ArticleDOI
TL;DR: It is found that the pattern of electrodes with the highest accuracy changed for each word, which supports the idea that closely spaced micro-electrodes are capable of capturing neural signals from independent neural processing assemblies.
Abstract: Pathological conditions such as amyotrophic lateral sclerosis or damage to the brainstem can leave patients severely paralyzed but fully aware, in a condition known as 'locked-in syndrome'. Communication in this state is often reduced to selecting individual letters or words by arduous residual movements. More intuitive and rapid communication may be restored by directly interfacing with language areas of the cerebral cortex. We used a grid of closely spaced, nonpenetrating micro-electrodes to record local field potentials (LFPs) from the surface of face motor cortex and Wernicke's area. From these LFPs we were successful in classifying a small set of words on a trial-by-trial basis at levels well above chance. We found that the pattern of electrodes with the highest accuracy changed for each word, which supports the idea that closely spaced micro-electrodes are capable of capturing neural signals from independent neural processing assemblies. These results further support using cortical surface potentials (electrocorticography) in brain-computer interfaces. These results also show that LFPs recorded from the cortical surface (micro-electrocorticography) of language areas can be used to classify speech-related cortical rhythms and potentially restore communication to locked-in patients.

241 citations

Journal ArticleDOI
TL;DR: Ammonium and potassium ion-selective membranes formulated with PVC, polyurethane/hydroxylated PVC, and moisture-curable silicone rubber matrices are studied in an effort to extend the lifetime of solid-state ion sensors through improved membrane adhesion.
Abstract: Ammonium and potassium ion-selective membranes formulated with PVC/hydroxylated PVC, polyurethane/hydroxylated PVC, and moisture-curable silicone rubber matrices are studied in an effort to extend the lifetime of solid-state ion sensors through improved membrane adhesion. The PVC/membranes exhibit electrochemical performance equivalent to that of conventional PVC membranes in terms of slope, detection limit, and selectivity. The polyurethane- and silicone-rubber-based membranes have better adhesion to silicon nitride than do PVC or hydroxylated PVC matrices. Incorporating a silanizing reagent (silicon tetrachloride) significantly improves the adhesion of the polyurethane matrix. The use of silicon tetrachloride in membrane matrices also enhances the electrochemical stability of the interfacial potential between ion-selective polymer-matrix membranes and silver epoxy inner reference electrodes of solid-state sensors. The biocompatibility of the polymer matrices is examined via radiotracer protein adsorption studies and whole blood clotting time measurements. The polyurethane- and silicone-rubber-based membranes exhibit less overall nonspecific protein adsorption than the PVC or hydroxylated PVC matrices.

149 citations

Proceedings ArticleDOI
01 May 1998
TL;DR: This paper introduces and demonstrates an extension to quadratic placement that accounts for wiring congestion, using an A* router and line-probe heuristics on region-based routing graphs to compute routing cost and shows improvements in wireability.
Abstract: This paper introduces and demonstrates an extension to quadratic placement that accounts for wiring congestion. The algorithm uses an A* router and line-probe heuristics on region-based routing graphs to compute routing cost. The interplay between routing analysis and quadratic placement using a growth matrix permits global treatment of congestion. Further reduction in congestion is obtained by the relaxation of pin constraints. Experiments show improvements in wireability.

142 citations

Journal ArticleDOI
TL;DR: The combination of accumulated techniques in semiconductor processing technology and the good mechanical properties of silicon led to the development of microelectromechanical systems (MEMS) in the early 1970s.
Abstract: Building on the invention of the transistor by Brattain and Bardeen, 1 an enormous amount of research in semiconductors and integrated circuits (ICs) has established the modern complementary metal -oxide-semiconductor (CMOS) technology. The combination of accumulated techniques in semiconductor processing technology and the good mechanical properties of silicon led to the development of microelectromechanical systems (MEMS) in the early 1970s. 2

134 citations


Cited by
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Proceedings ArticleDOI
02 Dec 2001
TL;DR: A new version of SimpleScalar that has been adapted to the ARM instruction set is used to characterize the performance of the benchmarks using configurations similar to current and next generation embedded processors.
Abstract: This paper examines a set of commercially representative embedded programs and compares them to an existing benchmark suite, SPEC2000. A new version of SimpleScalar that has been adapted to the ARM instruction set is used to characterize the performance of the benchmarks using configurations similar to current and next generation embedded processors. Several characteristics distinguish the representative embedded programs from the existing SPEC benchmarks including instruction distribution, memory behavior, and available parallelism. The embedded benchmarks, called MiBench, are freely available to all researchers.

3,548 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the transport properties of 50-nm-high 1D nanochannels on a chip and showed that they can be used for the separation and preconcentration of proteins.
Abstract: This thesis explores transport phenomena in nanochannels on a chip. Fundamental nanofluidic ionic studies form the basis for novel separation and preconcentration applications for proteomic purposes. The measurements were performed with 50-nm-high 1D nanochannels, which are easily accessible from both sides by two microchannels. Nanometer characteristic apertures were manufactured in the bonded structure of Pyrex-amorphous silicon – Pyrex, in which the thickness of the amorphous silicon layer serves as a spacer to define the height of the nanochannels. The geometry of the nanometer-sized apertures is well defined, which simplifies the modeling of the transport across them. Compared to biological pores, the present nanochannels in Pyrex offer increased stability. Fundamental characteristics of nanometer-sized apertures were obtained by impedance spectroscopy measurements of the nanochannel at different ionic strengths and pH values. A conductance plateau (on a log-log scale) was modeled and measured, establishing due to the dominance of the surface charge density in the nanochannels, which induces an excess of mobile counterions to maintain electroneutrality. The nanochannel conductance can be regulated at low ionic strengths by pH adjustment, and by an external voltage applied on the chip to change the zeta potential. This field-effect allows the regulation of ionic flow which can be exploited for the fabrication of nanofluidic devices. Fluorescence measurements confirm that 50-nm-high nanochannels show an exclusion of co-ions and an enrichment of counterions at low ionic strengths. This permselectivity is related to the increasing thickness of the electrical double layer (EDL) with decreasing salt concentrations, which results in an EDL overlap in an aperture if the height of the nanochannel and the thickness of the EDL are comparable in size. The diffusive transport of charged species and therefore the exclusion-enrichment effect was described with a simple model based on the Poisson-Boltzmann equation. The negatively charged Pyrex surface of the nanometer characteristic apertures can be inversed with chemical surface pretreatments, resulting in an exclusion of cations and an enrichment of anions. When a pressure gradient is applied across the nanochannels, charged molecules are electrostatically rejected at the entrance of the nanometer-sized apertures, which can be used for separation processes. Proteomic applications are presented such as the separation and preconcentration of proteins. The diffusion of Lectin proteins with different isoelectric points and very similar compositions were controlled by regulating the pH value of the buffer. When the proteins are neutral at their pI value, the diffusion coefficient is maximal because the biomolecules does not interact electrostatically with the charged surfaces of the nanochannel. This led to a fast separation of three Lectin proteins across the nanochannel. The pI values measured in this experiment are slightly shifted compared to the values obtained with isoelectric focusing because of reversible adsorption of proteins on the walls which affects the pH value in the nanochannel. An important application in the proteomic field is the preconcentration of biomolecules. By applying an electric field across the nanochannel, anionic and cationic analytes were preconcentrated on the cathodic side of the nanometer-sized aperture whereas on the anodic side depletion of ions was observed. This is due to concentration polarization, a complex of effects related to the formation of ionic concentration gradients in the electrolyte solution adjacent to an ion-selective interface. It was measured that the preconcentration factor increased with the net charge of the molecule, leading to a preconcentration factor of > 600 for rGFP proteins in 9 minutes. Such preconcentrations are important in micro total analysis systems to achieve increased detection signals of analytes contained in dilute solutions. Compared to cylindrical pores, our fabrication process allows the realization of nanochannels on a chip in which the exclusion-enrichment effect and a big flux across the nanometer-sized aperture can be achieved, showing the interest for possible micro total analysis system applications. The described exclusion-enrichment effect as well as concentration polarization play an important role in transport phenomena in nanofluidics. The appendix includes preliminary investigations in DNA molecule separation and fluorescence correlation spectroscopy measurements, which allows investigating the behavior of molecules in the nanochannel itself.

1,636 citations

Journal ArticleDOI
TL;DR: A material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin that provides new capabilities for implantable and surgical devices is described.
Abstract: Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical devices. Electronics that are capable of intimate integration with the surfaces of biological tissues create opportunities for improving animal/machine interfaces. A bio-interfaced system of ultrathin electronics supported by bioresorbable silk-fibroin substrates is now presented. Mounting such devices on tissue and then allowing the silk to dissolve initiates a conformal wrapping process that is driven by capillary forces.

1,522 citations