R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Dianhua Jiang,Jiurong Liang,Juan Fan,Shuang Yu,Suping Chen,Yi Luo,Glenn D. Prestwich,Marcella M. Mascarenhas,Hari G. Garg,Deborah A. Quinn,Robert J. Homer,Daniel R. Goldstein,Richard Bucala,Patty J. Lee,Ruslan Medzhitov,Paul W. Noble +15 more
TL;DR: It is reported that hyaluronan degradation products require MyD88 and both Toll-like receptor (TLR)4 and TLR2 in vitro and in vivo to initiate inflammatory responses in acute lung injury and epithelial cell apoptosis after lung injury.
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Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair.
TL;DR: Blood-borne fibrocytes contribute to scar formation and may play an important role both in normal wound repair and in pathological fibrotic responses.
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Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.
TL;DR: It is demonstrated that advanced glycosylation products quench nitric oxide activity in vitro and in vivo and that inhibition of advanced glyCosylation with aminoguanidine preventsNitric oxide quenching, and ameliorates the vasodilatory impairment.
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MIF as a glucocorticoid-induced modulator of cytokine production
Thierry Calandra,Jürgen Bernhagen,Christine N. Metz,Lori Spiegel,Michael Bacher,Thomas M. Donnelly,Anthony Cerami,Richard Bucala +7 more
TL;DR: The unexpected finding that low con-centrations of glucocorticoids induce rather than inhibit MIF production from macrophages is reported, identifying a unique counter-regulatory system that functions to control inflammatory and immune responses.
Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TL;DR: Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.