R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes.
Paul J. Beisswenger,Zenji Makita,Thomas J Curphey,Lynn L. Moore,Smith Jean,Truls Brinck-Johnsen,Richard Bucala,Helen Vlassara +7 more
TL;DR: Levels of collagen-linked AGEs, when measured by an AGE-specific ELISA, reveal a correlation with preclinical stages of diabetic nephropathy and early retinopathy not indicated by other methods and may prove useful as early markers of microangiopathy in type I diabetes.
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Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts
TL;DR: In this article, conditions obtained from fibroblasts cultured from rheumatoid and certain other inflammatory synovia were observed to stimulate [3H]thymidine incorporation in an indicator murine fibroblast line.
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Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells.
Katherine L. Meyer-Siegler,Kenneth A. Iczkowski,Kenneth A. Iczkowski,Lin Leng,Richard Bucala,Pedro L. Vera,Pedro L. Vera +6 more
TL;DR: Results showed greater cell surface CD74 in DU-145 prostate cancer cells that bind to MIF and, thus, mediate MIF-activated signal transduction, which may provide new, targeted specific therapies for androgen-independent prostate cancer.
Constitutive Production of Inflammatory and Mitogenic Cytokines by Rheumatoid
TL;DR: Persistent cytokine production by synovial fibroblasts may play an important role in the continued recruitment and activation of inflammatory cells in chronic arthritis and in the formation of rheumatoid pannus.
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Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria
TL;DR: Gram-positive exotoxins are extremely potent inducers of MIF secretion and establish a critical role for MIF and the macrophage in the pathogenesis of the TSSs and in the innate immune response.