R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
Papers
More filters
Journal ArticleDOI
Identification of N2-(1-carboxyethyl)guanine (CEG) as a guanine advanced glycosylation end product.
TL;DR: In every reaction involving 9-mG, N2-(1-carboxyethyl)-9-methylguanine (CEmG) was a major product which was produced and appears to result from the nucleophilic addition of the primary amino group of guanine to the ketone group of MG followed by an intramolecular rearrangement.
Journal ArticleDOI
Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion
TL;DR: Examining the role of MIF in regulating JNK activation and cardiac injury during experimental ischemia/reperfusion in mouse hearts indicates that endogenous MIF inhibits JNK pathway activation during reperfusion and protects the heart from injury.
Journal Article
Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha
Stefan Jüttner,Jürgen Bernhagen,Christine N. Metz,Martin Röllinghoff,Richard Bucala,André Gessner +5 more
TL;DR: It is reported that purified recombinant MIF activates murine macrophages to kill Leishmania major, with maximal effects at concentrations above 1 microg/ml, and the effect of MIF was blocked completely by the macrophage-deactivating cytokines IL-10, IL-13, and TGF-beta.
Journal ArticleDOI
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle.
Fabio Benigni,Toshiya Atsumi,Thierry Calandra,Christine N. Metz,Bernd Echtenacher,Tina Peng,Richard Bucala +6 more
TL;DR: An unexpected role is described for MIF in the regulation of glycolysis, which is associated with the recent finding that MIF is a positive, autocrine stimulator of insulin release, and suggest an important role for Mif in the control of host glucose disposal and carbohydrate metabolism.
Journal ArticleDOI
Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes
TL;DR: Serum sRAGE levels and circulating AGEs are associated with the severity of nephropathy in type 2 diabetic patients and Prospective studies are required to determine whether endogenous s RAGE potentially influences the development of diabetic vascular complications.