R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator
Nikolai Petrovsky,Nikolai Petrovsky,Luis Socha,Luis Socha,Diego G. Silva,Diego G. Silva,Arthur Robert Grossman,Christine N. Metz,Richard Bucala +8 more
TL;DR: The beneficial role of macrophage migration inhibitory factor neutralization in models of inflammatory arthritis is explained, by antagonizing cortisol‐mediated pro‐inflammatory cytokine suppression may prolong the duration of early morning inflammation.
Journal ArticleDOI
Macrophage migration inhibitory factor.
Elias Lolis,Richard Bucala +1 more
TL;DR: Unique structural features of MIF, including an intrinsic catalytic activity, offer attractive opportunities for the discovery and design of therapeutic MIF inhibitors.
Journal ArticleDOI
The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
Sachin Yende,Derek C. Angus,Lan Kong,John A. Kellum,Lisa A. Weissfeld,Robert E. Ferrell,David N. Finegold,Melinda Carter,Lin Leng,Zhi Yong Peng,Richard Bucala +10 more
TL;DR: In this article, two distinct polymorphisms in the MIF promoter were analyzed: a G/C transition at -173 and a CATT repeat at -794; however, the 90-d mortality was lower for the high-expression C allele (P=0.003) and the hazard ratio was similar in different geographic sub-cohorts, and the association remained significant after adjusting for false discovery.
Journal ArticleDOI
Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with increased prostate cancer incidence.
Katherine L. Meyer-Siegler,Pedro L. Vera,Kenneth A. Iczkowski,Carlo Bifulco,Annette Lee,Peter K. Gregersen,Lin Leng,Richard Bucala +7 more
TL;DR: Individuals with −173G/C, −173C/C and −794 7-CATT MIF genotypes have an increased incidence of CaP and these genotypes may serve as an independent marker for cancer recurrence.
Journal ArticleDOI
Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke.
TL;DR: It is concluded that MIF promotes neuronal death and aggravates neurologic deficits after experimental stroke, which implicates MIF in the pathogenesis of neuronal injury after stroke.