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Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Inhibition of advanced glycation endproduct formation by acetaldehyde: Role in the cardioprotective effect of ethanol
Yousef Al-Abed,Tomoko Mitsuhashi,Hongwei Li,John A. Lawson,Garret A. FitzGerald,Hank Founds,Thomas M. Donnelly,Anthony Cerami,Peter C. Ulrich,Richard Bucala +9 more
TL;DR: A possible mechanism for the so-called "French paradox," (the cardioprotection conferred by moderate ethanol ingestion) is suggested and new strategies for inhibiting advanced glycation are offered.
Journal ArticleDOI
Macrophage migration inhibitory factor is an important mediator in the pathogenesis of gastric inflammation in rats.
Xiao R. Huang,Connie Wun Chun Hui,Yongxiong Chen,Benjamin Chun,Yu Wong,Peter C. W. Fung,Christine N. Metz,Chi Hin Cho,Wai Mo Hui,Richard Bucala,Shiu Kum Lam,Hui Y. Lan +11 more
TL;DR: Inhibition of acute gastric ulcer by blockade of MIF indicates that MIF is a key inflammatory mediator and plays a pathogenic role in gastric inflammation.
Journal ArticleDOI
Sex Steroid Regulation of Macrophage Migration Inhibitory Factor in Normal and Inflamed Colon in the Female Rat
Eric Houdeau,Raphael Moriez,Mathilde Leveque,Christel Cartier,Aurelie Waget,Lin Leng,Lionel Bueno,Richard Bucala,Jean Fioramonti +8 more
TL;DR: Estrogen decreases while progesterone increases MIF production in the female rat colon, and changes in basal MIF contents may affect colon susceptibility to inflammation, by modulating TNF-alpha and IL-1beta production during early stages of colitis.
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The role of macrophage migration inhibitory factor in autoimmune liver disease
David N. Assis,Lin Leng,Xin Du,Clarence K. Zhang,Gerrit Grieb,Melanie Merk,Alvaro Baeza Garcia,Catherine H. McCrann,Julius Chapiro,Andreas Meinhardt,Yuka Mizue,David J. Nikolic-Paterson,Jürgen Bernhagen,Marshall M. Kaplan,Hongyu Zhao,James L. Boyer,Richard Bucala +16 more
TL;DR: The role of the cytokine, macrophage migration inhibitory factor (MIF), and its receptor, CD74, was assessed in autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) as mentioned in this paper.
Journal ArticleDOI
The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes.
Norihiko Sakai,Takashi Wada,Kouji Matsushima,Richard Bucala,Masaru Iwai,Masatsugu Horiuchi,Shuichi Kaneko +6 more
TL;DR: The results suggest that AT1R/AT2R signaling may contribute to the pathogenesis of renal fibrosis by at least two mechanisms: by regulating the number of fibrocytes in the bone marrow, and by activation of fib rocytes.