Richard Bucala

TL;DR: The findings demonstrate that variation in the MIF promoter influences susceptibility to SMA and peripheral MIF production, however, the Mif -173 and -794 polymorphisms appear to have both independent and interactive effects on different measures of disease severity, suggesting that MIF plays a complex role in malarial pathogenesis.

TL;DR: It is found that minodronate inhibited melanoma growth and improved survival in nude mice by suppressing the tumor-associated angiogenesis and macrophage infiltration and suppressing the VEGF signaling.

TL;DR: Anti-phospho-iPFK-2(Ser461) Western blotting revealed strong reactivity in insulin-treated 3T3-L1 adipocyte, suggesting that insulin induces the phosphorylation of PFKFB3 protein, expanding the role of these structurally unique iPFK- 2/PFKFB 3 isoforms in the metabolic regulation of adipocytes.

TL;DR: It is observed that the Plasmodium ortholog of macrophage migration inhibitory factor enhanced inflammatory cytokine production and also induced antigen-experienced CD4 T cells to develop into short-lived effector cells rather than memory precursor cells, indicating that PlasModia actively interfere with the development of immunological memory.

TL;DR: It is demonstrated that genetically controlled high MIF expression (and D-DT) promotes MS progression in males, suggesting that these two factors are sex-specific disease modifiers and raising the possibility that aggressive anti-MIF treatment of clinically isolated syndrome or RRMS males with a high-expresser genotype might slow or prevent the onset of progressive MS.