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Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Local Regulation of Macrophage Subsets in the Adult Rat Testis: Examination of the Roles of the Seminiferous Tubules, Testosterone, and Macrophage-Migration Inhibitory Factor
Andreas Meinhardt,Michael Bacher,Christine N. Metz,Richard Bucala,Nigel G. Wreford,Hui Lan,Robert C. Atkins,Mark P. Hedger +7 more
TL;DR: This study indicates that Leydig cells regulate testicular macrophage numbers directly, rather than via an effect upon the seminiferous epithelium, in the adult rat testis, and suggests that testosterone and MIF play only a minor role in this regulation.
Journal ArticleDOI
An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Georgios Pantouris,Mansoor Ali Syed,Chengpeng Fan,Deepa Rajasekaran,Thomas Yoonsang Cho,Eric M. Rosenberg,Richard Bucala,Vineet Bhandari,Elias Lolis +8 more
TL;DR: Using a novel approach, this work elucidates the mechanistic details that control activation of CD74 by MIF surface residues and identifies structural parameters of inhibitors that reduce CD74 biological activation.
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Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus.
TL;DR: In patients with RA and SLE and high expression MIF alleles, targeted MIF inhibition could be a precision medicine approach to treatment and anti-MIF pharmacotherapies could also be steroid-sparing in patients with chronic glucocorticoid dependence or refractory autoimmune disease.
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Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury, steatohepatitis, and steatosis
Mark A. Barnes,Megan R. McMullen,Sanjoy Roychowdhury,Sorana G. Pisano,Xiuli Liu,Abram B. Stavitsky,Abram B. Stavitsky,Richard Bucala,Laura E. Nagy +8 more
TL;DR: Analysis of the early response of wildtype and MIF−/− mice to ethanol indicates that MIF is an important mediator in the regulation of chemokine production and immune cell infiltration in the liver during ethanol feeding and promotes ethanol‐induced steatosis and hepatocyte damage.
Journal ArticleDOI
Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity
Peter Teismann,Peter Teismann,Kinnari Sathe,Angelika Bierhaus,Lin Leng,Heather Martin,Richard Bucala,Bernd Weigle,Peter P. Nawroth,Jörg B. Schulz,Jörg B. Schulz +10 more
TL;DR: It is suggested that activation of RAGE contributes to MPTP/MPP+-induced death of dopaminergic neurons that may be mediated by NF-κB activation.