R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
A New Class of Isothiocyanate-Based Irreversible Inhibitors of Macrophage Migration Inhibitory Factor
Hajer Ouertatani-Sakouhi,Farah El-Turk,Bruno Fauvet,Thierry Roger,Didier Le Roy,Damla Pinar Karpinar,Lin Leng,Richard Bucala,Markus Zweckstetter,Thierry Calandra,Hilal A. Lashuel +10 more
TL;DR: A new class of isothiocyanate (ITC)-based irreversible inhibitors of MIF is reported, highlighting the role of tertiary structure in modulating the biochemical and biological activities of Mif and present new opportunities for modulating MIF biological activities in vivo.
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Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia
TL;DR: The identification of MIF as a pituitary 'stress' hormone provides an important link in the regulation of systemic inflammatory responses by the central nervous system.
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A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome
Katharine Kevill,Vineet Bhandari,Mika Kettunen,Lin Leng,Juan Fan,Yuka Mizue,James Dzuira,Miguel Reyes-Múgica,Courtney McDonald,John A. Baugh,Christine L. O’Connor,Zubair H. Aghai,Seamas C. Donnelly,Alia Bazzy-Asaad,Richard Bucala +14 more
TL;DR: A central role for macrophage migration inhibitory factor (MIF) in lung maturation at the developmental stage when human neonates are most susceptible to RDS is demonstrated, and a protective role for MIF in newborn lung disease is supported.
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Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74
Sonja Djudjaj,Hongqi Lue,Song Rong,Marios Papasotiriou,Barbara M. Klinkhammer,Stephanie Zok,Ole Klaener,Gerald S. Braun,Maja T. Lindenmeyer,Clemens D. Cohen,Richard Bucala,André P. Tittel,Christian Kurts,Marcus J. Moeller,Juergen Floege,Tammo Ostendorf,Jürgen Bernhagen,Peter Boor +17 more
TL;DR: In murine crescentic GN, Mif-deficient mice were almost completely protected from glomerular injury, the development of cellular crescents, and the activation and proliferation of PECs and mesangial cells, whereas wild-type mice were not.
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Macrophage migration inhibitory factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway.
TL;DR: The aim of this study was to investigate the signaling mechanism by which MIF induces MMP-9 expression and activation in a murine macrophage line (RAW264.7), and the functional role of mitogen-activated protein kinase kinase (MEK)-ERK MAP kinase in MIF-induced M MP- 9 expression was confirmed.