R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Compartmentalized Protective and Detrimental Effects of Endogenous Macrophage Migration-Inhibitory Factor Mediated by CXCR2 in a Mouse Model of Myocardial Ischemia/Reperfusion
Elisa A. Liehn,Isabella Kanzler,Simone Konschalla,Andreas Kroh,Sakine Simsekyilmaz,Tolga Taha Sönmez,Richard Bucala,Jürgen Bernhagen,Christian Weber +8 more
TL;DR: Although MIF confers protective effects by improving myocardial healing and function through CXCR2 in resident cells, thereby complementing paracrine effects through CD74/AMP-activated protein kinase, it exerts detrimental effects on CxCR2-bearing inflammatory cells by increasing monocyte infiltration and impairing heart function.
Journal ArticleDOI
TAp63 Regulates VLA-4 Expression and Chronic Lymphocytic Leukemia Cell Migration to the Bone Marrow in a CD74-Dependent Manner
Inbal Binsky,Frida Lantner,Valentin Grabovsky,Nurit Harpaz,Lev Shvidel,Alain Berrebi,David M. Goldenberg,Lin Leng,Richard Bucala,Ronen Alon,Michal Haran,Idit Shachar +11 more
TL;DR: This study shows that stimulation of CD74 with its natural ligand, migration inhibitory factor, initiates a signaling cascade that results in upregulation of TAp63, which directly regulates CLL survival and could form the basis of novel therapeutic strategies aimed at blocking homing of CLL cells in their return to the BM and attenuating their survival.
Journal ArticleDOI
The emerging role of MIF in septic shock and infection.
TL;DR: The protein mediator described originally as macrophage migration inhibitory factor has been “re-discovered” recently to be both a novel pituitary hormone and a pro-inflammatory, Macrophage-derived cytokine.
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Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques.
Yao Zhong Kong,Xiao R. Huang,Xiaosen Ouyang,Jei Ju Tan,Gunter Fingerle-Rowson,Michael Bacher,Wei Mu,Larry A. Scher,Lin Leng,Richard Bucala,Hui Y. Lan +10 more
TL;DR: The ability of MIF to induce MMP-1 expression and collagenolytic activity in VSMCs suggests that MIF may play a role in the destabilization of human atherosclerotic plaques.
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Involvement of Macrophage Migration Inhibitory Factor (MIF) in Experimental Uric Acid Nephropathy
Yoon-Goo Kim,Xiao-Ru Huang,Shinichi Suga,Marilda Mazzali,Dongjiang Tang,Christine N. Metz,Richard Bucala,Salah D. Kivlighn,Richard J. Johnson,Hui Y. Lan +9 more
TL;DR: Intrarenal granulomas in urate nephropathy may be the consequence of a crystal induced DTH reaction mediated by MIF, which is a known mediator of delayed type hypersensitivity (DTH).