R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Nephrogenic systemic fibrosis and gadolinium exposure: association and lessons for idiopathic fibrosing disorders.
Journal ArticleDOI
Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication.
Eduardo G. Regis,Victor Barreto-de-Souza,Mariza G. Morgado,Marcelo T. Bozza,Lin Leng,Richard Bucala,Dumith Chequer Bou-Habib +6 more
TL;DR: The results show that HIV-1 induces MIF secretion and suggest that MIF influences the HIV-3 biology through activation of HIV-2 LTR, while using a T CD4(+) cell lineage containing an HIV long terminal repeats (LTR)-Luciferase construct, it is detected that rhMIF promotes transcription from HIV- 1 LTR.
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Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages.
TL;DR: It is shown that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.
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Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
TL;DR: In this article, it was shown that NAPQI has a catalytic site similar to the tautomerase/isomerase sites of microbial enzymes and has been shown to inhibit MIF both covalently and noncovalently.
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Macrophage Migration Inhibitory Factor Enzymatic Activity, Lung Inflammation, and Cystic Fibrosis
Huzaifa Adamali,Michelle E. Armstrong,Anne Marie McLaughlin,Gordon Cooke,Edward F. McKone,Christine M. Costello,Charles G. Gallagher,Lin Leng,John A. Baugh,Gunter Fingerle-Rowson,Richard Bucala,Paul McLoughlin,Seamas C. Donnelly +12 more
TL;DR: MIF-tautomerase activity may provide a novel therapeutic target in patients with chronic inflammatory diseases such as CF, particularly those patients who are genetically predisposed to produce increased levels of this cytokine.