R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Neuroimmunomodulation by macrophage migration inhibitory factor (MIF).
TL;DR: Anti‐MIF therapeutic strategies are under development and may prove to be a means to increase the immunosuppressive and anti‐inflammatory properties of endogenously released glucocorticoids, thereby reducing the requirement for steroid therapy in a variety of autoimmune and inflammatory conditions.
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Benzisothiazolones as modulators of macrophage migration inhibitory factor.
TL;DR: Substituted N-phenylbenzisothiazolones have been investigated as inhibitors of the tautomerase activity of the proinflammatory cytokine MIF and were found to retard the MIF-dependent phosphorylation of ERK1/2 in human synovial fibroblasts.
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Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus
TL;DR: Glycoxidized LDL was more potent than oxLDL in inducing LOX-1 in vitro and the relationship between sLOX- 1 and apoB-CML was independent of HbA1c, age, gender, BMI and smoking status.
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Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
Christos Kontos,Omar El Bounkari,Christine Krammer,Dzmitry Sinitski,Kathleen Hille,Chunfang Zan,Guangyao Yan,Sijia Wang,Ying Gao,Markus Brandhofer,Remco T. A. Megens,Adrian Hoffmann,Jessica Pauli,Yaw Asare,Simona Gerra,Priscila Bourilhon,Lin Leng,Hans-Henning Eckstein,W.E. Kempf,Jaroslav Pelisek,Jaroslav Pelisek,Ozgun Gokce,Lars Maegdefessel,Richard Bucala,Martin Dichgans,Christian Weber,Aphrodite Kapurniotu,Juergen Bernhagen +27 more
TL;DR: An engineered GPCR-ectodomain-based mimicry principle is established that differentiates between disease-exacerbating and -protective pathways and chemokine-selectively interferes with atherosclerosis.
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Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation
Jeffrey N. Weiser,Aoife M. Roche,Christopher B. Hergott,Meredith I. LaRose,Tarah M. Connolly,William L. Jorgensen,Lin Leng,Richard Bucala,Rituparna Das +8 more
TL;DR: It is demonstrated that MIF modulates beneficial versus detrimental inflammatory responses in the host-pneumococcal interaction and is a potential target for therapeutic modulation.