R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Functional Polymorphisms in the
Rituparna Das,Lakshman Subrahmanyan,Ivana V. Yang,Rebecca Levy,Marta Piecychna,Lin Leng,Ruth R. Montgomery,Albert C. Shaw,David A. Schwartz,Richard Bucala +9 more
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Macrophage migration inhibitory factor promotes eosinophil accumulation and tissue remodeling in eosinophilic esophagitis.
H S de Souza,C A Tortori,L Lintomen,Rodrigo T. Figueiredo,Claudio Bernardazzi,Lin Leng,Richard Bucala,Kalil Madi,Fernanda Buongusto,Celeste C. Elia,Morgana T. Castelo-Branco,Marcelo T. Bozza +11 more
TL;DR: In a model of EoE induced by ovalbumin, Mif-deficient mice have reduced inflammation and collagen deposition compared with wild-type (WT) mice, and it is suggested that targeting MIF might represent a novel therapy for EeE.
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Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia.
Bong-Sung Kim,Bong-Sung Kim,Bong-Sung Kim,Pathricia V. Tilstam,Kevin Arnke,Lin Leng,Tim Ruhl,Marta Piecychna,Wibke Schulte,Maor Sauler,Florian S. Frueh,Gabriele Storti,Nicole Lindenblatt,Pietro Giovanoli,Norbert Pallua,Jürgen Bernhagen,Richard Bucala +16 more
TL;DR: Data suggest an inverse relationship between adipocyte MIF and Mif‐2 expression during systemic inflammation, with the downregulation of MIF‐2 in fat tissue potentially increasing pro‐inflammatory macrophage polarization to further drive adipose inflammation.
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Ostertagia ostertagi macrophage migration inhibitory factor is present in all developmental stages and may cross-regulate host functions through interaction with the host receptor.
Guanggang Qu,R. H. Fetterer,Lin Leng,Xin Du,Dante S. Zarlenga,Zhiqiang Shen,Wenyu Han,Richard Bucala,Wenbin Tuo +8 more
TL;DR: Macrophage migration inhibitory factor of Ostertagia ostertagi, an abomasal parasite of cattle, was characterised in the present study and Immunostaining indicated that macrophages were able to internalise rOos-MIF-1.1, further supporting receptor-mediated transportation.
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Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine.
Anja Scholzen,Guilhem Richard,Leonard Moise,Laurie A. Baeten,Patrick Reeves,William D. Martin,Timothy Brauns,Christine M. Boyle,Susan Raju Paul,Richard Bucala,Richard A. Bowen,Anja Garritsen,Anne S. De Groot,Ann E. Sluder,Mark C. Poznansky +14 more
TL;DR: It is demonstrated that a substantial proportion of immunoinformatically identified HLA class II epitopes show long-lived immunoreactivity in naturally infected individuals, making them desirable candidates for a novel human multi-epitope Q fever vaccine.