R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease.
Akihiro Nakamura,Fanxing Zeng,S. Nakamura,Kyle T. Reid,Kyle T. Reid,Eric Gracey,Melissa Lim,Lin Leng,Sungsin Jo,Ye-Soo Park,Masaki Kusuda,Rohan Machhar,Shaghayegh Foroozan Boroojeni,Shaghayegh Foroozan Boroojeni,Brian Wu,E. Rossomacha,Tae-Hwan Kim,Francesco Ciccia,Jason S. Rockel,Mohit Kapoor,Robert D. Inman,Igor Jurisica,Sarah Q. Crome,Sarah Q. Crome,Richard Bucala,Nigil Haroon +25 more
TL;DR: A type 3 immunity-mediated inflammatory arthritis, spondyloarthritis, is a systemic rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes as discussed by the authors.
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Neutralization of macrophage migration inhibitory factor improves host survival after Clostridium difficile infection.
Shinsmon Jose,Anindita Mukherjee,Mayuresh M. Abhyankar,Lin Leng,Richard Bucala,Divya Sharma,Rajat Madan,Rajat Madan +7 more
TL;DR: Patients with CDI had significantly higher circulating MIF compared to patients who had diarrhea but tested negative for C. difficile, and use of anti-MIF antibodies may represent a therapeutic strategy to curb host inflammatory responses and improve disease outcomes in CDI.
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Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.
Georgios Pantouris,Deepa Rajasekaran,Alvaro Baeza Garcia,Victor G. Ruiz,Lin Leng,William L. Jorgensen,Richard Bucala,Elias Lolis +7 more
TL;DR: This study reports the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor with nanomolar Ki’s and provides explanations regarding their selectivity of PfMIF versus human MIF.
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Macrophage Migration Inhibitory Factor (MIF) Drives Murine Psoriasiform Dermatitis
Siegfried Bezdek,Lin Leng,Hauke Busch,Sadegh Mousavi,Dirk Rades,Markus Dahlke,Detlef Zillikens,Richard Bucala,Christian D. Sadik +8 more
TL;DR: The role of MIF is addressed in two mouse models of psoriasis, namely in the imiquimod-induced psoriasiform dermatitis (IIPD) and the IL-23-induced dermatitis model, to lend support to a possible disease-promoting role of the immunomodulator.
Journal ArticleDOI
Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Lynn Jeanette Savic,Luzie A. Doemel,Isabel Schobert,Ruth R. Montgomery,Nikhil Joshi,John J. Walsh,Jessica G Santana,Vasily Pekurovsky,Xuchen Zhang,MingDe Lin,Lucas Christoph Adam,Annemarie Boustani,James S. Duncan,Lin Leng,Richard Bucala,S. Nahum Goldberg,Fahmeed Hyder,Daniel Coman,Julius Chapiro +18 more
TL;DR: MRI in a rabbit liver tumor model was used to visualize resistance mechanisms mediated by the immunosuppressive tumor micro-environments that inform susceptibility and response to immuno-oncologic therapies, providing a therapeutic strategy to restore immune permissiveness in liver cancer.