Author
Richard Bucala
Other affiliations: École Polytechnique Fédérale de Lausanne, Rockefeller University, Metz ...read more
Bio: Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
Papers published on a yearly basis
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TL;DR: The important role of the neuroendocrine system in immune regulation is demonstrated by the increased susceptibility of hypophysectomized or adrenalectomized animals to death from septic shock and one of the most significant recently identified factors is macrophage migration inhibitory factor.
Abstract: The development and subsequent abatement of an immune response depends upon a complex interplay of humoral and cellular mediators. Cytokines function in this process by recruiting and activating effector cells which fight infection or tissue invasion. Unopposed cytokine action may lead, however, to excess tissue destruction and ultimately prove fatal unless held in check by counterbalancing regulatory forces. The important role of the neuroendocrine system in immune regulation is demonstrated by the increased susceptibility of hypophysectomized or adrenalectomized animals to death from septic shock. 1 Not surprisingly, in view of their close relationship, an increasing number of mediators of neuroendocrine and immune communication have been identified. One of the most significant recently identified factors with both neuroendocrine and immune roles is macrophage migration inhibitory factor (MIF).
15 citations
TL;DR: While Genebank analysis identifying mif-like genes across species is extensive, contained herein is an overview of the non-mammalian MIF-like proteins that have been most well studied experimentally.
14 citations
TL;DR: It is revealed that CD74 ablation counteracts acute ethanol challenge-induced myocardial dysfunction, inflammation and apoptosis possibly through an AMPK-mTOR-Skp2-mediated regulation of autophagy.
14 citations
TL;DR: Examination of functional polymorphisms in the MIF locus in a cohort of 454 North American patients with neuroinvasive WNV disease found patients homozygous for high-expression MIF alleles to be >20-fold more likely to have WNV encephalitis, indicating that MIF is an important determinant of severity of WNV neuropathogenesis and may be a therapeutic target.
14 citations
TL;DR: Since HDAC3 carries strong potential to be a tumor suppressor gene, it is reported herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband.
Abstract: Histone deacetylases have been described as crucial cofactors of mammalian transcriptional complexes. We have recently identified human histone deacetylase HDAC3 on chromosome 5q31 by fluorescence in situ hybridization (FISH) in a region commonly deleted in malignant myeloid disease. Since HDAC3 carries strong potential to be a tumor suppressor gene, we report herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband.
14 citations
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TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.
Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …
33,785 citations
Journal Article•
28,685 citations
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Abstract: Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.
20,479 citations
28 Jul 2005
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations