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Richard D. Wood
Researcher at University of Texas MD Anderson Cancer Center
Publications - 207
Citations - 23483
Richard D. Wood is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: DNA repair & Nucleotide excision repair. The author has an hindex of 81, co-authored 202 publications receiving 22406 citations. Previous affiliations of Richard D. Wood include University of California, Berkeley & University of Cambridge.
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Journal ArticleDOI
Human DNA Repair Genes
TL;DR: Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.
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Quality control by DNA repair.
Tomas Lindahl,Richard D. Wood +1 more
TL;DR: In some cases, DNA damage is not repaired but is instead bypassed by specialized DNA polymerases, and the integrity of the genetic information is compromised.
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Mammalian DNA nucleotide excision repair reconstituted with purified protein components.
Abdelilah Aboussekhra,Maureen Biggerstaff,Mahmud K.K. Shivji,Juhani Vilpo,Vincent Moncollin,Vladimir N. Podust,Miroslava Protić,Ulrich Hübscher,Jean-Marc Egly,Richard D. Wood +9 more
TL;DR: Nucleotide excision repair is the principal way by which human cells remove UV damage from DNA by combining DNA polymerase epsilon, RFC, PCNA, and DNA ligase I with ERCC1- and XPF-correcting activity.
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Proliferating cell nuclear antigen is required for DNA excision repair.
TL;DR: The ability to visualize repair intermediates in the absence of PCNA facilitates dissection of the multiprotein reaction that leads to incision of damaged DNA in a major pathway of cellular defense against mutagens.
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DNA Repair in Eukaryotes
TL;DR: Double-strand breaks in DNA are repaired by mechanisms that involve recombination proteins and, in mammalian cells, a DNA protein kinase, and different DNA polymerases and ligases are used to complete the separate pathways.