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Richard Durbin
Researcher at University of Cambridge
Publications - 337
Citations - 247542
Richard Durbin is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome & Population. The author has an hindex of 125, co-authored 319 publications receiving 207192 citations. Previous affiliations of Richard Durbin include Wellcome Trust Sanger Institute & University of Manchester.
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Journal ArticleDOI
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel
Jie Huang,Bryan Howie,Shane A. McCarthy,Yasin Memari,Klaudia Walter,Josine L. Min,Petr Danecek,Giovanni Malerba,Elisabetta Trabetti,Hou-Feng Zheng,Hou-Feng Zheng,Giovanni Gambaro,J. Brent Richards,Richard Durbin,Nicholas J. Timpson,Jonathan Marchini,Jonathan Marchini,Nicole Soranzo,Nicole Soranzo +18 more
TL;DR: It is shown that large increases in imputation accuracy can be achieved by re-phasing WGS reference panels after initial genotype calling, and a method for combining WGS panels to improve variant coverage and downstream imputations accuracy is presented.
Journal ArticleDOI
Genomic islands of speciation separate cichlid ecomorphs in an East African crater lake.
Milan Malinsky,Milan Malinsky,Richard Challis,Alexandra M. Tyers,Stephan Schiffels,Yohey Terai,Benjamin P. Ngatunga,Eric A. Miska,Eric A. Miska,Richard Durbin,Martin J. Genner,George F. Turner +11 more
TL;DR: The discovery and detailed characterization of early-stage adaptive divergence of two cichlid fish ecomorphs in a small crater lake in Tanzania are reported and mechanisms and genomic regions that may play a role in the closely related mega-radiation of Lake Malawi are suggested.
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TreeFam: 2008 Update
Jue Ruan,Heng Li,Zhongzhong Chen,Avril Coghlan,Lachlan J. M. Coin,Yiran Guo,Jean-Karim Hériché,Yafeng Hu,Karsten Kristiansen,Ruiqiang Li,Tao Liu,Alan M. Moses,Junjie Qin,Søren Vang,Albert J. Vilella,Abel Ureta-Vidal,Lars Bolund,Jun Wang,Richard Durbin +18 more
TL;DR: Release 4.0 of TreeFam contains curated trees for 1314 families and automatically generated trees for another 14 351 families, and introduces more accurate approaches for automatically grouping genes into families, for building phylogenetic trees, and for inferring orthologues and paralogues.
Journal ArticleDOI
Whole-genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow
Milan Malinsky,Hannes Svardal,Alexandra M. Tyers,Alexandra M. Tyers,Eric A. Miska,Eric A. Miska,Martin J. Genner,George F. Turner,Richard Durbin +8 more
TL;DR: In this paper, the authors characterized the genomic diversity of cichlid fish in Lake Malawi by sequencing 134 individuals covering 73 species across all major lineages and found that the average sequence divergence between species pairs is only 0.1-0.25%.
Journal ArticleDOI
Ensembl’s 10th year
Paul Flicek,Bronwen Aken,Benoit Ballester,Kathryn Beal,Eugene Bragin,Simon Brent,Yuan Chen,Peter Clapham,Guy Coates,Susan Fairley,Stephen Fitzgerald,Julio Fernandez-Banet,Leo Gordon,Stefan Gräf,Syed Haider,Martin Hammond,Kerstin Howe,Andrew M. Jenkinson,Nathan Johnson,Andreas Kähäri,Damian Keefe,Stephen Keenan,Rhoda Kinsella,Felix Kokocinski,Gautier Koscielny,Eugene Kulesha,Daniel Lawson,Ian Longden,Tim Massingham,William M. McLaren,Karyn Megy,Bert Overduin,Bethan Pritchard,Daniel Rios,Magali Ruffier,Michael Schuster,Guy Slater,Damian Smedley,Giulietta Spudich,Y. Amy Tang,Stephen J. Trevanion,Albert J. Vilella,Jan Hinnerk Vogel,Simon D. M. White,Steven P. Wilder,Amonida Zadissa,Ewan Birney,Fiona Cunningham,Ian Dunham,Richard Durbin,Xosé M. Fernández-Suárez,Javier Herrero,Tim Hubbard,Anne Parker,Glenn Proctor,James Smith,Stephen M. J. Searle +56 more
TL;DR: Major additions and improvements to Ensembl since the previous report include the incorporation of the human GRCh37 assembly, enhanced visualisation and data-mining options for the Ensemblembl regulatory features and continued development of the software infrastructure.