R
Richard Durbin
Researcher at University of Cambridge
Publications - 337
Citations - 247542
Richard Durbin is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome & Population. The author has an hindex of 125, co-authored 319 publications receiving 207192 citations. Previous affiliations of Richard Durbin include Wellcome Trust Sanger Institute & University of Manchester.
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Efficiently inferring the demographic history of many populations with allele count data
TL;DR: A new method for efficiently computing the expected SFS and linear functionals of it, for demographies described by general directed acyclic graphs is presented, which can scale to more populations than previously possible for complex demographic histories including admixture.
Journal ArticleDOI
Evidence for an independent hydrogen-ion pump in the stomach.
E. Heinz,Richard Durbin +1 more
Journal ArticleDOI
Enhanced protein domain discovery by using language modeling techniques from speech recognition
TL;DR: This work discovers an unannotated Tf_Otx Pfam domain on the cone rod homeobox protein, which suggests a possible mechanism for how the V242M mutation on this protein causes cone-rod dystrophy.
A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans (vol 5, 4871, 2015)
N J Timpson,Klaudia Walter,J L Min,I Tachmazidou,G Malerba,S-Y Shin,L Chen,M Futema,L Southam,Iotchkova,M Cocca,Jie Huang,Yasin Memari,Shane A. McCarthy,P Danecek,D Muddyman,Massimo Mangino,C Menni,Jrb Perry,Susan M. Ring,A Gaye,George Dedoussis,A-E Farmaki,P Burton,PJ Talmud,G Gambaro,Tim D. Spector,GD Smith,Richard Durbin,JB Richards,SE Humphries,E Zeggini,Nicole Soranzo +32 more
Journal ArticleDOI
Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.
Zhihao Ding,Yunyun Ni,Sander W. Timmer,Bum Kyu Lee,Anna Battenhouse,Sandra Louzada,Fengtang Yang,Ian Dunham,Gregory E. Crawford,Jason D. Lieb,Richard Durbin,Vishwanath R. Iyer,Ewan Birney +12 more
TL;DR: The data reveal extensive genetic effects on CTCF binding, both direct and indirect, and identify a diversity of patterns of C TCF binding on the X chromosome.