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Richard Durbin
Researcher at University of Cambridge
Publications - 337
Citations - 247542
Richard Durbin is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome & Population. The author has an hindex of 125, co-authored 319 publications receiving 207192 citations. Previous affiliations of Richard Durbin include Wellcome Trust Sanger Institute & University of Manchester.
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Journal ArticleDOI
Managing clinically significant findings in research: the UK10K example.
Jane Kaye,Matthew E. Hurles,Heather Griffin,Jasjote Grewal,Martin Bobrow,Nic Timpson,Carol Smee,Patrick Bolton,Richard Durbin,Stephanie O.M. Dyke,David R. FitzPatrick,Karen Kennedy,Alastair Kent,Dawn Muddyman,Francesco Muntoni,Lucy Raymond,Robert K. Semple,Tim D. Spector +17 more
TL;DR: This paper describes the mechanism and the specific criteria, which must be fulfilled in order for a finding and participant to qualify for feedback, and could be used by future research consortia, and may also assist in the development of sound principles for dealing with CSFs.
Journal ArticleDOI
Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels
Ian Sudbery,Jim Stalker,Jared T. Simpson,Thomas M. Keane,Alistair G. Rust,Matthew E. Hurles,Klaudia Walter,Dee Lynch,Lydia Teboul,Steve D.M. Brown,Heng Li,Zemin Ning,Joseph H. Nadeau,Colleen M. Croniger,Richard Durbin,David J. Adams +15 more
TL;DR: Approaches for the accurate identification of nucleotide and structural variation in the genomes of vertebrate experimental organisms are described and how these techniques can be applied to help prioritize candidate genes within quantitative trait loci are shown.
Posted ContentDOI
Ancestral hybridisation facilitated species diversification in the Lake Malawi cichlid fish adaptive radiation
Hannes Svardal,Fu Xiang Quah,Milan Malinsky,Benjamin P. Ngatunga,Eric A. Miska,Eric A. Miska,Walter Salzburger,Martin J. Genner,George F. Turner,Richard Durbin,Richard Durbin +10 more
TL;DR: The results reinforce the role of ancestral hybridisation in explosive diversification by demonstrating its significance in one of the largest recent vertebrate adaptive radiations of cichlid fishes in East Afrian Lake Malawi.
Journal ArticleDOI
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
Johann Hawe,Rory P. Wilson,Katharina T Schmid,Li Zhou,Lakshmi Narayanan Lakshmanan,Benjamin Lehne,Brigitte Kühnel,William R. Scott,Matthias Wielscher,Yik Weng Yew,Clemens Baumbach,Dominic Paul Lee,Eirini Marouli,Manon Bernard,Liliane Pfeiffer,Pamela R. Matias-Garcia,Matias I. Autio,Stephane Bourgeois,Christian Herder,Ville Karhunen,Thomas Meitinger,Holger Prokisch,Wolfgang Rathmann,Michael Roden,Sylvain Sebert,Jean Shin,Konstantin Strauch,Weihua Zhang,Wilson Lek Wen Tan,Stefanie M. Hauck,Juliane Merl-Pham,Harald Grallert,Eudes Gv Barbosa,Kourosh R. Ahmadi,Chrysanthi Ainali,Amy Barrett,Veronique Bataille,Jordana T. Bell,Alfonso Buil,Emmanouil T. Dermitzakis,Antigone S. Dimas,Richard Durbin,Daniel Glass,Elin Grundberg,Neelam Hassanali,Åsa K. Hedman,Catherine E. Ingle,David A. Knowles,Maria Krestyaninova,Cecilia M. Lindgren,Christopher E. Lowe,Mark I. McCarthy,Eshwar Meduri,Paola Di Meglio,Josine L. Min,Stephen B. Montgomery,Frank O. Nestle,Alexandra C. Nica,James Nisbet,Stephen O'Rahilly,Leopold Parts,Simon C. Potter,Johanna K. Sandling,Magda Sekowska,So-Youn Shin,Kerrin S. Small,Nicole Soranzo,Tim D. Spector,Gabriela L. Surdulescu,Mary E. Travers,Loukia Tsaprouni,Sophia Tsoka,Alicja Wilk,Tsun-Po Yang,Krina T. Zondervan,Thomas Illig,Annette Peters,Tomáš Paus,Zdenka Pausova,Panos Deloukas,Roger Foo,Marjo-Ritta Jarvelin,Jaspal S. Kooner,Marie Loh,Matthias Heinig,Christian Gieger,Melanie Waldenberger,John C. Chambers +87 more
TL;DR: In this article , the authors determined the relationship between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians, and identified 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P < 10−14), including 467,915 meQTL that operate in trans.
Journal ArticleDOI
The anatomy of successful computational biology software.
Stephen F. Altschul,Barry Demchak,Richard Durbin,Robert Gentleman,Martin Krzywinski,Heng Li,Anton Nekrutenko,James T. Robinson,Wayne Rasband,James Taylor,Cole Trapnell +10 more
TL;DR: Creators of software widely used in computational biology discuss the factors that contributed to their success and suggest ideas for future generations of software developers.