Richard Durbin

TL;DR: It is demonstrated that aligning aDNA sequences to variation graphs effectively mitigates the impact of reference bias when analyzing aDNA, while retaining mapping sensitivity and allowing detection of variation, in particular indel variation, that was previously missed.

TL;DR: Overall HLOF genes are enriched for olfactory receptor function and are expressed in testes more often than expected, consistent with reduced purifying selection and incipient pseudogenisation.

TL;DR: A program called pseudogene inference from loss of constraint (PSILC) is introduced which incorporates novel methods for separating pseudogenes from functional genes and it is shown that both these methods result in a more accurate classification of Pseudogenes than dN/dS when a Pfam domain alignment is available.

TL;DR: No single non-synonymous (NS) single nucleotide variant (SNV) nor any gene carrying a higher burden of NS SNVs was significantly associated with PD status after multiple-testing correction, but significant enrichments of genes whose proteins have roles in the extracellular matrix were amongst the top 300 genes with the most significantly associated NSSNVs.

TL;DR: The genomes of 73 cichlid fish species from Lake Malawi uncover evolutionary processes underlying a large adaptive evolutionary radiation, and enhance the understanding of genomic processes underlying rapid species diversification.