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Richard Durbin
Researcher at University of Cambridge
Publications - 337
Citations - 247542
Richard Durbin is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome & Population. The author has an hindex of 125, co-authored 319 publications receiving 207192 citations. Previous affiliations of Richard Durbin include Wellcome Trust Sanger Institute & University of Manchester.
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Posted ContentDOI
Genomics of cold adaptations in the Antarctic notothenioid fish radiation
Iliana Bista,Jonathan Wood,Thomas Desvignes,Shane A. McCarthy,Michael Matschiner,Zemin Ning,Alan Tracey,James Torrance,Ying Sims,William Chow,Michelle Smith,Karen Oliver,Leanne Haggerty,Walter Salzburger,John H. Postlethwait,Kerstin Howe,Melody S. Clark,William H. Detrich,C.-H. Christina Cheng,Eric A. Miska,Richard Durbin +20 more
TL;DR: A new estimate for the onset of the radiation of notothenioids at 10.7 million years ago is presented, a two-fold variation in genome size is identified, driven by expansion of multiple transposable element families, and two evolutionarily important, highly repetitive gene family loci are reconstructed.
Book ChapterDOI
[19] Oscillation method with large unit cells
TL;DR: In this article, the use of a fast, low-background film together with a modern rotating drum microdensitometer provides an efficient and suitably accurate technique for the quantitative measurement of X-ray diffraction intensities from crystals of large unit cell.
Journal ArticleDOI
Environmental Genomics of Late Pleistocene Black Bears and Giant Short-Faced Bears
Mikkel Winther Pedersen,Bianca De Sanctis,Nedda F. Saremi,Martin Sikora,Emily E. Puckett,Zhenquan Gu,Katherine L. Moon,Joshua D. Kapp,Lasse Vinner,Zaruhi Vardanyan,Ciprian F. Ardelean,Joaquín Arroyo-Cabrales,James A. Cahill,Peter D. Heintzman,Grant D. Zazula,Ross D. E. MacPhee,Beth Shapiro,Richard Durbin,Eske Willerslev +18 more
TL;DR: The ability to separately analyse genomic-scale DNA sequences of closely related species co-preserved in environmental samples is demonstrated, which brings the use of ancient eDNA into the era of population genomics and phylogenetics.
Posted ContentDOI
Reference-based phasing using the Haplotype Reference Consortium panel
Po-Ru Loh,Petr Danecek,Pier Francesco Palamara,Christian Fuchsberger,Yakir A. Reshef,Hilary K. Finucane,Sebastian Schoenherr,Lukas Forer,Shane A. McCarthy,Gonçalo R. Abecasis,Richard Durbin,Alkes L. Price +11 more
TL;DR: A new phasing algorithm, Eagle2, is introduced that attains high accuracy across a broad range of cohort sizes by efficiently leveraging information from large external reference panels (such as the Haplotype Reference Consortium, HRC) using a new data structure based on the positional BurrowsWheeler transform.
Journal ArticleDOI
False gene and chromosome losses in genome assemblies caused by GC content variation and repeats
Juwan Kim,Chul-Ho Lee,Byung June Ko,DongAhn Yoo,Sohyoung Won,Adam M. Phillippy,Olivier Fedrigo,Guojie Zhang,Kerstin Howe,Jonathan Wood,Richard Durbin,Giulio Formenti,Samara Brown,Lindsey J. Cantin,Claudio V. Mello,Seo Ae Cho,Arang Rhie,Heebal Kim,Erich D. Jarvis +18 more
TL;DR: The Vertebrate Genomes Project has been producing new reference genome assemblies with an emphasis on being as complete and error-free as possible, which requires utilizing long reads, long-range scaffolding data, new assembly algorithms, and manual curation as discussed by the authors .