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Richard G. Pestell
Researcher at Wistar Institute
Publications - 494
Citations - 58557
Richard G. Pestell is an academic researcher from Wistar Institute. The author has contributed to research in topics: Cyclin D1 & Cyclin D. The author has an hindex of 130, co-authored 479 publications receiving 54210 citations. Previous affiliations of Richard G. Pestell include University of North Carolina at Chapel Hill & Yeshiva University.
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Journal ArticleDOI
Stat3 as an Oncogene
Jacqueline Bromberg,Melissa H. Wrzeszczynska,Geeta Devgan,Yanxiang Zhao,Richard G. Pestell,Chris Albanese,James E. Darnell +6 more
TL;DR: Substitution of two cysteine residues within the C-terminal loop of the SH2 domain of Stat3 produces a molecule that dimerizes spontaneously, binds to DNA, and activates transcription.
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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
Michael Shtutman,Jacob Zhurinsky,Inbal Simcha,Chris Albanese,Mark D'Amico,Richard G. Pestell,Avri Ben-Ze'ev +6 more
TL;DR: Increased beta-catenin levels may promote neoplastic conversion by triggering cyclin D1 gene expression and, consequently, uncontrolled progression into the cell cycle through a LEF-1 binding site in the cyclinD1 promoter.
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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
TL;DR: It is shown that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1, and is identified as an important transcriptional target of NF-α, revealing a mechanism to explain how NF-β is involved in the early phases of the cell cycle to regulate cell growth and differentiation.
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Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
Babak Razani,Jeffery A. Engelman,Xiaobo Wang,William Schubert,Xiao Lan Zhang,Carolyn Marks,Frank P. Macaluso,Robert G. Russell,Maomi Li,Richard G. Pestell,Dolores Di Vizio,Harry Hou,Burkhard Kneitz,Guy Lagaud,George J. Christ,Winfried Edelmann,Michael P. Lisanti +16 more
TL;DR: The results indicate that eNOS activity is up-regulated in Cav-1 null animals, and this activity can be blunted by using a specific NOS inhibitor, nitro-l-arginine methyl ester.
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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Stephanos Pavlides,Diana Whitaker-Menezes,Remedios Castello-Cros,Neal Flomenberg,Agnieszka K. Witkiewicz,Philippe G. Frank,Mathew C. Casimiro,Chenguang Wang,Paolo Fortina,Sankar Addya,Richard G. Pestell,Ubaldo E. Martinez-Outschoorn,Federica Sotgia,Michael P. Lisanti +13 more
TL;DR: In this alternative model of tumorigenesis, the epithelial cancer cells instruct the normal stroma to transform into a wound-healing stroma, providing the necessary energy-rich micro-environment for facilitating tumor growth and angiogenesis, explaining its powerful predictive value.