R
Richard H. Weisbart
Researcher at Veterans Health Administration
Publications - 90
Citations - 5177
Richard H. Weisbart is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Antibody & Autoantibody. The author has an hindex of 31, co-authored 89 publications receiving 5027 citations. Previous affiliations of Richard H. Weisbart include University of California, Los Angeles & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator.
TL;DR: It is reported here that PMNs preincubated with either purified natural GM-CSF or biosynthetic (recombinant) GM- CSF showed increased (as much as fourfold) Superoxide anion production in response to f-MLP, indicating that human GM-SF is a neutrophil-activating factor.
Journal ArticleDOI
Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils.
Judith C. Gasson,Richard H. Weisbart,Susan E. Kaufman,Steven C. Clark,Rodney M. Hewick,Gordon G. Wong,David W. Golde +6 more
TL;DR: A human lymphokine that modulates the activities of mature neutrophilic granulocytes is also a colony-stimulating factor acting on precursors to induce growth and differentiation of new effector cells.
Journal ArticleDOI
Human GM-CSF primes neutrophils for enhanced oxidative metabolism in response to the major physiological chemoattractants
TL;DR: The results suggest that GM-CSF may be an endogenous regulator of neutrophil inflammatory responses induced by the major physiological chemoattractants.
Journal ArticleDOI
Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils.
TL;DR: Results indicate that another effect of GM-CSF on the mature neutrophil is the enhancement of phagocytosis.
Journal ArticleDOI
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.
Lixia Zhao,Qiu-Lan Ma,Qiu-Lan Ma,Frédéric Calon,Marni E. Harris-White,Marni E. Harris-White,Fusheng Yang,Fusheng Yang,Giselle P. Lim,Giselle P. Lim,Takashi Morihara,Oliver J. Ubeda,Oliver J. Ubeda,Surendra S. Ambegaokar,Surendra S. Ambegaokar,James E. Hansen,James E. Hansen,Richard H. Weisbart,Richard H. Weisbart,Bruce Teter,Bruce Teter,Sally A. Frautschy,Greg M. Cole +22 more
TL;DR: It is shown that PAK and its activity are markedly reduced in Alzheimer disease and that this is accompanied by reduced and redistributed phosphoPAK, prominent cofilin pathology and downstream loss of the spine actin-regulatory protein drebrin, which cofilIn removes from actin.