R
Richard K. Wilson
Researcher at Nationwide Children's Hospital
Publications - 501
Citations - 294778
Richard K. Wilson is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 173, co-authored 463 publications receiving 260000 citations. Previous affiliations of Richard K. Wilson include University of Washington & St. Jude Children's Research Hospital.
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Journal ArticleDOI
C11orf95 – RELA fusions drive oncogenic NF-κB signalling in ependymoma
Matthew Parker,Kumarasamypet M. Mohankumar,Chandanamali Punchihewa,Ricardo Weinlich,James Dalton,Yongjin Li,Ryan P. Lee,Ruth G. Tatevossian,Timothy N. Phoenix,Radhika Thiruvenkatam,Elsie White,Bo Tang,Wilda Orisme,Kirti Gupta,Michael Rusch,Xiang Chen,Yuxin Li,Panduka Nagahawhatte,Erin Hedlund,David Finkelstein,Gang Wu,Sheila A. Shurtleff,John Easton,Kristy Boggs,Donald Yergeau,Bhavin Vadodaria,Heather L. Mulder,Jared Becksford,Pankaj Gupta,Robert Huether,Jing Ma,Guangchun Song,Amar Gajjar,Thomas E. Merchant,Frederick A. Boop,Amy A Smith,Li Ding,Charles Lu,Kerri Ochoa,David Zhao,Robert S. Fulton,Lucinda Fulton,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Douglas R. Green,Jinghui Zhang,David W. Ellison,Richard J. Gilbertson +48 more
TL;DR: The data identify a highly recurrent genetic alteration of RELA in human cancer, and the C11orf95–RELA fusion protein as a potential therapeutic target in supratentorial ependymoma.
Journal ArticleDOI
CREST maps somatic structural variation in cancer genomes with base-pair resolution
Jianmin Wang,Charles G. Mullighan,John Easton,Stefan Roberts,Susan L. Heatley,Jing Ma,Michael Rusch,Ken Chen,Chris Harris,Li Ding,Linda Holmfeldt,Debbie Payne-Turner,Xian Fan,Lei Wei,David Zhao,John C. Obenauer,Clayton W. Naeve,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang +20 more
TL;DR: Application of CREST to whole-genome sequencing data from five pediatric T-lineage acute lymphoblastic leukemias and a human melanoma cell line, COLO-829, identified 160 somatic structural variations.
Journal ArticleDOI
Oil palm genome sequence reveals divergence of interfertile species in Old and New worlds
Rajinder Singh,Meilina Ong-Abdullah,Eng Ti Leslie Low,Mohamad Arif Abdul Manaf,Rozana Rosli,Rajanaidu Nookiah,Leslie Cheng-Li Ooi,Siew Eng Ooi,Kuang-Lim Chan,Mohd Amin Ab Halim,Norazah Azizi,Jayanthi Nagappan,Blaire Bacher,Nathan D. Lakey,Steven W. Smith,Dong He,Michael Hogan,Muhammad A. Budiman,Ernest K. Lee,Rob DeSalle,David Kudrna,Jose Luis Goicoechea,Rod A. Wing,Richard K. Wilson,Robert S. Fulton,Jared M. Ordway,Robert A. Martienssen,Ravigadevi Sambanthamurthi +27 more
TL;DR: The oil palm sequence enables the discovery of genes for important traits as well as somaclonal epigenetic alterations that restrict the use of clones in commercial plantings, and should therefore help to achieve sustainability for biofuels and edible oils, reducing the rainforest footprint of this tropical plantation crop.
Journal ArticleDOI
CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
Malachi Griffith,Nicholas C. Spies,Kilannin Krysiak,Joshua F. McMichael,Adam C. Coffman,Arpad Danos,Benjamin J. Ainscough,Cody Ramirez,Damian T. Rieke,Lynzey Kujan,Erica K. Barnell,Alex H. Wagner,Zachary L. Skidmore,Amber Z. Wollam,Connor J. Liu,Martin R. Jones,Rachel L. Bilski,Robert Lesurf,Yan Yang Feng,Nakul M. Shah,Melika Bonakdar,Lee Trani,Matthew K. Matlock,Avinash Ramu,Katie M. Campbell,Gregory C. Spies,Aaron P. Graubert,Karthik Gangavarapu,James M. Eldred,David E. Larson,Jason Walker,Benjamin M. Good,Chunlei Wu,Andrew I. Su,Rodrigo Dienstmann,Adam A. Margolin,David Tamborero,Nuria Lopez-Bigas,Steven J.M. Jones,Ron Bose,David H. Spencer,Lukas D. Wartman,Richard K. Wilson,Elaine R. Mardis,Obi L. Griffith +44 more
TL;DR: CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types.
Journal ArticleDOI
Modernizing Reference Genome Assemblies
Deanna M. Church,Valerie A. Schneider,Tina Graves,Katherine Auger,Fiona Cunningham,Nathan Bouk,Hsiu Chuan Chen,Richa Agarwala,William M. McLaren,Graham R. S. Ritchie,Derek Albracht,Milinn Kremitzki,Susan M. Rock,Holland Kotkiewicz,Colin Kremitzki,Aye Wollam,Lee Trani,Lucinda Fulton,Robert S. Fulton,Lucy Matthews,S. Whitehead,William Chow,James Torrance,Matthew Dunn,Glenn Harden,Glen Threadgold,Jonathan Wood,Joanna Collins,Paul Heath,Guy Griffiths,Sarah Pelan,Darren Grafham,Evan E. Eichler,Evan E. Eichler,George M. Weinstock,Elaine R. Mardis,Richard K. Wilson,Kerstin Howe,Paul Flicek,Tim Hubbard +39 more
TL;DR: Support for this work came from the Intramural Research Program of the NIH, The National Library of Medicine, the European Molecular Biology Laboratory, the Wellcome Trust, and the Howard Hughes Medical Institute.