Showing papers by "Richard Lathe published in 1995"
TL;DR: Hct-1 (hippocampal transcript) was detected in a differential screen of a rat hippocampal cDNA library as discussed by the authors, which revealed extensive homologies with cytochrome P450s, a diverse family of heme-binding monooxygenases that metabolize a range of substrates including steroids, fatty acids, and xenobiotics.
154 citations
TL;DR: The independent evolution of at least two distinct pathological 144 base pair insertions in Britain is proposed and the importance of maintaining a high index of suspicion of inherited Creutzfeldt-Jakob disease in cases of familial neurodegenerative disease is stressed.
Abstract: A case of familial Creutzfeldt-Jakob disease associated with a 144 base pair insertion in the open reading frame of the prion protein gene is described. Sequencing of the mutated allele showed an arrangement of six octapeptide repeats, distinct from that of a recently described British family with an insertion of similar size. Thirteen years previously the brother of the proband had died from "Huntington's disease", but re-examination of his neuropathology revealed spongiform encephalopathy and anti-prion protein immunocytochemistry gave a positive result. The independent evolution of at least two distinct pathological 144 base pair insertions in Britain is proposed. The importance of maintaining a high index of suspicion of inherited Creutzfeldt-Jakob disease in cases of familial neurodegenerative disease is stressed.
47 citations
TL;DR: The deduced marsupial PrP has an overall identity of about 80% to eutherian PrP at the amino acid (aa) level, but this similarity is not equally distributed and two regions are particularly highly conserved.
40 citations
Patent•
07 Jun 1995
TL;DR: A pharmaceutical composition which comprises a recombinant vaccinia virus containing a DNA fragment encoding for a polypeptide recognized by a particular antibody H23, which recognizes a particular tumor antigen expressed on breast cancer cells is provided in this article.
Abstract: A pharmaceutical composition which comprises a recombinant vaccinia virus containing a DNA fragment encoding for a polypeptide recognized by a particular antibody H23, which recognizes a particular tumor antigen expressed on breast cancer cells is provided The antibody specifically binds to an epitope comprising a tandem repeat sequence of 20 amino acids comprised in a transmembrane form as well as a secreted form of the POLYPEPTIDES specifically bound by antibody H23
27 citations
Patent•
18 Oct 1995
TL;DR: L'utilisation de sondes d'hybridation basees sur la sequence Hct-1 du rat a permis l'identification d'homologues chez d'autres especes mammiferes.
Abstract: La presente invention concerne de nouvelles proteines associees a l'hippocampe ainsi que les sequences ADN permettant leur codage. Lors d'une recherche par criblage differentiel menee sur les proteines associees a l'hippocampe dans la banque genomique de l'hippocampe d'un rat, on a isole une espece d'ADN-c codant une nouvelle proteine appelee Hct-1 et on a montre que cette espece etait liee aux cytochromes P-450. L'utilisation de sondes d'hybridation basees sur la sequence Hct-1 du rat a permis l'identification d'homologues chez d'autres especes mammiferes.