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Richard Lathe
Researcher at University of Edinburgh
Publications - 179
Citations - 20987
Richard Lathe is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 52, co-authored 172 publications receiving 19962 citations. Previous affiliations of Richard Lathe include Centre national de la recherche scientifique & University of Strasbourg.
Papers
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Journal ArticleDOI
The firA gene, a locus involved in the expression of rifampicin resistance in Escherichia coli - II. Characterisation of bacterial proteins coded by λfirA transducing phages
Richard Lathe,Jean-Pierre Lecocq +1 more
TL;DR: Evidence is presented to suggest that this protein may be identical to the Kappa factor of Schäfer and Zillig (1973), showing that it is present in the cell in large quantities.
Journal ArticleDOI
Mechanism Underlying Tissue Cryotherapy to Combat Obesity/Overweight: Triggering Thermogenesis
Suvaddhana Loap,Richard Lathe +1 more
TL;DR: It is argued that cold-induced thermogenesis rather than adipocyte disruption underlies the reduction in AT volume, raising the prospect that more intensive cryotherapy may be a viable option for combating obesity and overweight.
Patent
Expression vehicles and their use in the preparation of a protein having human alpha-antitrypsin activity
Michael Courtney,Anne Buchwalder,Luc-Henri Tessier,Michael Jaye,Richard Lathe,Paul Tolstoshev,Jean-Pierre Lecocq +6 more
TL;DR: A vector for the clonal selection and the expression of a gene determined in a gram-negative bacteria, comprising: the origin of replication of a bacterial plasmid; a promotor of the bacteriophage lambda : PL, PR or P'R; a region coding for the initiation of the translation; a clonal region comprising unic restrictions sites, and a plasmID, comprising all or part of the sequence coding for human antitrypsin- alpha 1 and particularly a vector as described here above as mentioned in this paper.
Journal ArticleDOI
Analysing brain function and dysfunction in transgenic animals.
TL;DR: This work focuses on the hippocampus, a brain region involved in learning and memory and an early target for degeneration in Alzheimer's disease, and has yielded transgenic animals with apparent functional deficits in the hippocampus leading the way to a greater understanding of brain function.