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Richard Lathe

Researcher at University of Edinburgh

Publications -  179
Citations -  20987

Richard Lathe is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 52, co-authored 172 publications receiving 19962 citations. Previous affiliations of Richard Lathe include Centre national de la recherche scientifique & University of Strasbourg.

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Mono-allelic expression of variegating transgene locus in the mouse.

Margaret L. Opsahl, +5 more
- 01 Dec 2003 - 
TL;DR: To investigate whether this variegated expression profile can be affected by the introduction of an identical variegating locus on the homologous chromosome, a comparison of β-lactoglobulin expression profiles in mice hemizygous or homozygous for the transgene locus was compared.
Posted ContentDOI

Antiherpetic medication and incident dementia: observational cohort studies in four countries

Christian Schnier, +10 more
- 04 Dec 2020 - 
TL;DR: A meta-analysis of the association between herpesvirus infection and dementia concluded that the evidence for an association to date is insufficient, with a tendency towards decreased dementia risk in individuals exposed to antiherpetic medication.
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Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathy.

Richard Lathe, +2 more
- 01 Mar 2020 - 
TL;DR: A strong case is to be made that a second element – retroelement nucleic acid – bound to PrP constitutes the second component necessary to explain the multiple strains of TSE.
Journal ArticleDOI

Fusion of restriction termini using synthetic adaptor oligonucleotides

Richard Lathe, +3 more
- 01 Dec 1982 - 
TL;DR: Synthetic oligonucleotide adaptors can be used to change the site specificity at the termini of a fragment generated by restriction enzyme cleavage and simultaneously dephosphorylate the extremities of a DNA molecule to prevent recircularisation and allow positive selection for recombinant DNA molecules.
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Development of Animal Recombinant DNA Vaccine and Its Efficacy in Foxes

Marie Paule Kieny, +6 more
- 01 Nov 1988 - 
TL;DR: Inoculation of live recombinant virus via the subcutaneous, intradermal, or oral routes uniformly elicited high titers of neutralizing antibodies, and animals that received 10(8) plaque-forming units of the recombinantirus in bait resisted severe challenge with live rabies virus.