Richard Lathe

Bio: Richard Lathe is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 52, co-authored 172 publications receiving 19962 citations. Previous affiliations of Richard Lathe include Centre national de la recherche scientifique & University of Strasbourg.

Proteines associees a l'hippocampe, leur codage par sequences adn et utilisation de ces proteines

Abstract: La presente invention concerne de nouvelles proteines associees a l'hippocampe ainsi que les sequences ADN permettant leur codage. Lors d'une recherche par criblage differentiel menee sur les proteines associees a l'hippocampe dans la banque genomique de l'hippocampe d'un rat, on a isole une espece d'ADN-c codant une nouvelle proteine appelee Hct-1 et on a montre que cette espece etait liee aux cytochromes P-450. L'utilisation de sondes d'hybridation basees sur la sequence Hct-1 du rat a permis l'identification d'homologues chez d'autres especes mammiferes.

Restricted access data in the neurosciences: Are the restrictions always justified?

Abstract: COPYRIGHT © 2023 Lathe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Restricted access data in the neurosciences: Are the restrictions always justified?

Production of hydroxylated or acetylated steroids, useful for treating nervous system disorders, comprises incubating precursor with yeast transformed with cyp7b gene

Abstract: Production (M1) of hydroxylated and/or acetylated steroids (I) comprising growing yeast on a medium containing at least one precursor (II) for (I), where the yeast used has been transformed to express the product of the cyp7b gene, is new. Independent claims are also included for the following: (1) (I) produced by M1; (2) a yeast strain lacking 17-dehydrogenase activity because of inactivation of the gene yil124w; and (3) a yeast strain transformed with a plasmid that contains a cassette for expressing the cyp7b gene.

Genetically Engineered Rabies Subunit Vaccines

Abstract: The attempt to control the proliferation of rabies virus remains a major preoccupation of health authorities worldwide. Effective vaccines based upon inactivated rabies virus have been developed, however the cost of these preparations has impeded systematic preventive vaccination. The techniques of genetic engineering therefore present an attractive alternative.

The chemosensory brain requires a distributed cellular mechanism to harness information and resolve conflicts - is consciousness the forum?

Abstract: The central nervous system (CNS) evolved from a chemosensory epithelium, but a simple epithelium has limited means to resolve conflicts between early drives (e.g., approach vs. avoid). Understanding the role of "consciousness" as a resolution device, with specific focus on chemosensation and the olfactory system, is of appeal. I argue that consciousness is not the adjudicator, but is instead the forum that brings conflicting (conscious) inputs into a form that allows them to be (unconsciously) compared/contrasted, guiding rational action.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Abstract: An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

Vascular endothelial growth factor is a secreted angiogenic mitogen

Abstract: Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo. Complementary DNA clones for bovine and human VEGF were isolated from cDNA libraries prepared from FC and HL60 leukemia cells, respectively. These cDNAs encode hydrophilic proteins with sequences related to those of the A and B chains of platelet-derived growth factor. DNA sequencing suggests the existence of several molecular species of VEGF. VEGFs are secreted proteins, in contrast to other endothelial cell mitogens such as acidic or basic fibroblast growth factors and platelet-derived endothelial cell growth factor. Human 293 cells transfected with an expression vector containing a bovine or human VEGF cDNA insert secrete an endothelial cell mitogen that behaves like native VEGF.

Feature-Oriented Domain Analysis (FODA) Feasibility Study

Abstract: : Successful Software reuse requires the systematic discovery and exploitation of commonality across related software systems. By examining related software systems and the underlying theory of the class of systems they represent, domain analysis can provide a generic description of the requirements of that class of systems and a set of approaches for their implementation. This report will establish methods for performing a domain analysis and describe the products of the domain analysis process. To illustrate the application of domain analysis to a representative class of software systems, this report will provide a domain analysis of window management system software.

Unified models for active galactic nuclei and quasars

Abstract: Because the critical central regions of Active Galactic Nuclei (AGN) and quasars are strongly nonspherical but spatially unresolved, orientation effects have been the source of much confusion. In fact, it now appears that much of the variety in AGN types is just the result of varying orientation relative to the line of sight. We can define an extreme hypothesis,, the straw person model (SPM), in which there are two basic types of AGN: the radio quiets and the radio louds. For each type there is a range in intrinsic luminosity, and the luminosity controls some properties such as the Fanaroff and Riley classes. However, at a given intrinsic luminosity, all other properties such as spectroscopic classification and VLBI component speeds are ascribed to orientation. This model is only a caricature of the unification idea, and is already ruled out on many grounds, but it will be useful for organizing the discussion. I’ll describe what I consider to be convincing evidence that orientation effects are important and widespread. The true situation may be in some sense half way between the SPM and the hypothesis that orientation doesn’t affect classification at aIl. To us optimists, the orienration cup is half full rather than half empty. Although it is too soon to say for sure, the hypothesis that most objects’ classifications would be different if seen from other directions is a tenable one today.