R
Richard Lathe
Researcher at University of Edinburgh
Publications - 179
Citations - 20987
Richard Lathe is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 52, co-authored 172 publications receiving 19962 citations. Previous affiliations of Richard Lathe include Centre national de la recherche scientifique & University of Strasbourg.
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Journal ArticleDOI
The individuality of mice
TL;DR: Genetic differences due to minisatellite variation suggest that each mouse is genetically distinct, and how such effects amplify the behavioral spectrum displayed by otherwise identical animals will improve testing is considered.
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Variegated gene expression in mice
Kenneth W. Dobie,Kenneth W. Dobie,Kenneth W. Dobie,Majid Mehtali,M McClenaghan,Richard Lathe +5 more
TL;DR: Growing evidence now suggests that some transgenes can be subject to a phenomenon akin to the variegation found in insects and plants, which can complicate the interpretation of some experiments using transgenic animals generated by microinjection.
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Improved antigenicity of the HIV env protein by cleavage site removal
Marie-Paule Kieny,Richard Lathe,Y. Rlvlère,Karin Dott,D. Schmitt,M. Girard,L. Montagnler,J P Lecocq +7 more
TL;DR: Analysis of variants revealed that the gp120 moiety is alone capable of interacting with CD4 and of provoking aggregation of T4+ lymphocytes, whereas cell-associated gp41 liberated by gp160 cleavage was essential for cell fusion.
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Dehydroepiandrosterone 7-hydroxylase cyp7b: predominant expression in primate hippocampus and reduced expression in alzheimer's disease☆
Joyce L.W. Yau,Sigbritt Rasmuson,Ruth Andrew,Margaret C. Graham,June Noble,Tommy Olsson,Eberhard Fuchs,Richard Lathe,Jonathan R. Seckl +8 more
TL;DR: It is shown that the reaction is conserved across mammalian species: in addition to mouse and rat, DHEA hydroxylation activity was present in brain extracts from sheep, marmoset and human.
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Pharmaceuticals from transgenic livestock
TL;DR: The possibility that transgenic methodology may be applied to the production of human therapeutic proteins in farm animals is discussed, and the theoretical, technical and financial aspects of the approach are examined.