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Richard M. Mortensen

Researcher at University of Michigan

Publications -  95
Citations -  8418

Richard M. Mortensen is an academic researcher from University of Michigan. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Gene. The author has an hindex of 40, co-authored 91 publications receiving 7753 citations. Previous affiliations of Richard M. Mortensen include Duke University & Brigham and Women's Hospital.

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Journal ArticleDOI

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

Evan D. Rosen, +7 more
- 01 Oct 1999 - 
TL;DR: It is demonstrated here that mice chimeric for wild-type and PPARγ null cells show little or no contribution of null cells to adipose tissue, whereas most other organs examined do not require PParγ for proper development.
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The role of PPAR-γ in macrophage differentiation and cholesterol uptake

Kathryn J. Moore, +11 more
- 01 Jan 2001 - 
TL;DR: In wild-type macrophages, TZD treatment divergently regulated CD36 and class A macrophage-scavenger receptor expression and failed to induce significant cellular cholesterol accumulation, indicating that TZDs may not exacerbate Macrophage foam-cell formation.
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Production of homozygous mutant ES cells with a single targeting construct.

Richard M. Mortensen, +4 more
- 01 May 1992 - 
TL;DR: A simple method for producing embryonic stem (ES) cell lines whereby both alleles have been inactivated by homologous recombination and which requires a single targeting construct, which provides an easy method for obtaining homozygous mutationally altered cells.
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Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

Michael G. Usher, +7 more
- 01 Sep 2010 - 
TL;DR: It is shown that myeloid MR is an important control point in macrophage polarization and that the function of MR on myeloids cells likely represents a conserved ancestral MR function that is integrated in a transcriptional network with PPARgamma and glucocorticoid receptor.
Journal Article

Anticancer Effects of Thiazolidinediones Are Independent of Peroxisome Proliferator-activated Receptor γ and Mediated by Inhibition of Translation Initiation

Sangeetha Palakurthi, +4 more
- 15 Aug 2001 - 
TL;DR: It is reported here that inhibition of cell proliferation and tumor growth by TZDs is independent of PPARgamma, which most likely accounts for the anticancer properties of thiazolidinediones.