R
Richard T. Lee
Researcher at Georgia Regents University
Publications - 863
Citations - 68598
Richard T. Lee is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 131, co-authored 810 publications receiving 62164 citations. Previous affiliations of Richard T. Lee include Garvan Institute of Medical Research & Albert Einstein College of Medicine.
Papers
More filters
Journal ArticleDOI
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Shannon L. Stott,Chia-Hsien Hsu,Chia-Hsien Hsu,Chia-Hsien Hsu,Dina Tsukrov,Min Yu,David T. Miyamoto,Belinda A. Waltman,S. Michael Rothenberg,Ajay Shah,Malgorzata E. Smas,George K. Korir,Frederick P. Floyd,Anna J. Gilman,Jenna B. Lord,Daniel Winokur,Simeon Springer,Daniel Irimia,Daniel Irimia,Sunitha Nagrath,Sunitha Nagrath,Lecia V. Sequist,Lecia V. Sequist,Richard T. Lee,Richard T. Lee,Kurt J. Isselbacher,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Mehmet Toner,Mehmet Toner +30 more
TL;DR: A high-throughput microfluidic mixing device, the herringbone-chip, or “HB-Chip,” is described, which provides an enhanced platform for CTC isolation and reveals microclusters of CTCs, previously unappreciated tumor cell aggregates that may contribute to the hematogenous dissemination of cancer.
Journal ArticleDOI
Stem-cell therapy for cardiac disease
TL;DR: In conclusion, resident cardiac stem cells have been shown to differentiate into multiple cell types present in the heart, including cardiac muscle cells, indicating that the heart is not terminally differentiated.
Journal ArticleDOI
Mammalian heart renewal by pre-existing cardiomyocytes
Samuel E. Senyo,Matthew L. Steinhauser,Christie L Pizzimenti,Vicky K. Yang,Lei Cai,Mei Wang,Ting-Di Wu,Ting-Di Wu,Jean-Luc Guerquin-Kern,Jean-Luc Guerquin-Kern,Claude Lechene,Richard T. Lee,Richard T. Lee +12 more
TL;DR: It is found that cell cycle activity during normal ageing and after injury led to polyploidy and multinucleation, but also to new diploid, mononucleate cardiomyocytes.
Journal ArticleDOI
Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
Emre Ozkumur,Ajay Shah,Jordan C. Ciciliano,Benjamin L. Emmink,David T. Miyamoto,Elena F. Brachtel,Min Yu,Min Yu,Pin-i Chen,Bailey Morgan,Julie Trautwein,Anya Kimura,Sudarshana Sengupta,Shannon L. Stott,Nezihi Murat Karabacak,Tom Barber,John R. Walsh,Kyle C. Smith,Philipp S. Spuhler,James P. Sullivan,Richard T. Lee,David T. Ting,Xi Luo,Xi Luo,Alice T. Shaw,Aditya Bardia,Lecia V. Sequist,David N. Louis,Shyamala Maheswaran,Ravi Kapur,Daniel A. Haber,Daniel A. Haber,Mehmet Toner +32 more
TL;DR: A multistage microfluidic device that is capable of sorting rare circulating tumor cells (CTCs) that are either positive or negative for the surface antigen epithelial cell adhesion molecule (EpCAM) and could be a promising addition to current diagnostic tools used in the clinic is developed.
Journal ArticleDOI
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Jan Lammerding,P. Christian Schulze,Tomosaburo Takahashi,Serguei Kozlov,Teresa Sullivan,Roger D. Kamm,Colin L. Stewart,Richard T. Lee +7 more
TL;DR: The findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation.